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The Journal of Urology
Volume 178, Issue 5
, Pages 1846-1854
, November 2007
Novel Targeted Pro-Apoptotic Agents for the Treatment of Prostate Cancer
References
- National Prostate Cancer Coalition: Prostate Cancer Facts and Statistics. Available at: www.fightprostatecancer.org. Accessed October 27, 2006.
- . New strategies for the medical treatment of prostate cancer. BJU Int. 2005;96(suppl):35
- Implication of cell kinetic changes during the progression of human prostatic cancer. Clin Cancer Res. 1995;1:473
- . Targeting apoptosis pathways in cancer therapy. CA Cancer J Clin. 2005;55:178
- . Mitochondrial regulation of apoptotic cell death. Toxicol Lett. 2004;149:19
- . Apoptotic pathways: ten minutes to dead. Cell. 2005;121:671
- . Serial killers: ordering caspase activation events in apoptosis. Cell Death Differ. 1999;6:1067
- . Loss of caspase-1 and caspase-3 protein expression in human prostate cancer. Cancer Res. 2001;61:1227
- . The flip side of FLIP. Biochem J. 2004;382:e1
- Androgen receptor and prostate apoptosis response factor-4 target the c-FLIP gene to determine survival and apoptosis in the prostate gland. J Mol Endocrinol. 2006;36:463
- . Persistent c-FLIP(L) expression is necessary and sufficient to maintain resistance to tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in prostate cancer. Cancer Res. 2004;64:7086
- . Doxorubicin pretreatment sensitizes prostate cancer cell lines to TRAIL induced apoptosis which correlates with the loss of c-FLIP expression. Cancer Biol Ther. 2002;1:520
- . Death to the bad guys: targeting cancer via Apo2L/TRAIL. Apoptosis. 2005;10:35
- Combined treatment of colorectal tumours with agonistic TRAIL receptor antibodies HGS-ETR1 and HGS-ETR2 and radiotherapy: enhanced effects in vitro and dose-dependent growth delay in vivo. Oncogene. 2006;25:5145
- Humphreys R, Shepard L, Poortman C, Shields E, Johnson R, Gillotte D et al: HGS-TR2J, a human, agonistic, TRAIL receptor-2 monoclonal antibody, induces apoptosis, tumor regression and growth inhibition as a single agent in diverse human solid tumor cell lines. Presented at European Organisation for the Treatment of Cancer-National Cancer Institute-American Association for Cancer Research Symposium on Molecular Targets and Cancer Therapeutics, Geneva, Switzerland, September 28-October 1, 2004.
- 15-Deoxy-delta12,14-prostaglandin J(2) induces death receptor 5 expression through mRNA stabilization independently of PPARgamma and potentiates TRAIL-induced apoptosis. Mol Cancer Ther. 2006;5:1827
- . Cell death: critical control points. Cell. 2004;116:205
- . Sensitization of prostate carcinoma cells to Apo2L/TRAIL by a Bcl-2 family protein inhibitor. Apoptosis. 2005;10:1411
- Phase 1 and pharmacodynamic studies of G3139, a Bcl-2 antisense oligonucleotide, in combination with chemotherapy in refractory or relapsed acute leukemia. Blood. 2003;101:425
- A novel antisense oligonucleotide inhibiting several antiapoptotic Bcl-2 family members induces apoptosis and enhances chemosensitivity in androgen-independent human prostate cancer PC3 cells. Mol Cancer Ther. 2005;4:1689
- Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy. Cancer Cell. 2005;7:227
- Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix. Science. 2004;305:1466
- A stapled BID BH3 helix directly binds and activates BAX. Mol Cell. 2006;24:199
- . Drug insight: use of docetaxel in prostate and urothelial cancers. Nat Clin Pract Urol. 2005;2:92
- Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity. Cancer Cell. 2004;5:25
- Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells. Blood. 2005;105:4043
- Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database. J Med Chem. 2004;47:2430
- . A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death. Science. 2004;305:1471
- The bortezomib/proteasome inhibitor PS-341 and triterpenoid CDDO-Im induce synergistic anti-multiple myeloma (MM) activity and overcome bortezomib resistance. Blood. 2004;103:3158
- . Interfering with cell-survival signalling as a treatment strategy for prostate cancer. BJU Int. 2006;97:1149
- Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma. J Clin Oncol. 2004;22:909
- . Inhibitors of mammalian target of rapamycin as novel antitumor agents: from bench to clinic. Curr Opin Investig Drugs. 2002;3:295
- The role of IKK in constitutive activation of NF-kappaB transcription factor in prostate carcinoma cells. J Cell Sci. 2002;115:141
- . Silibinin inhibits constitutive and TNFalpha-induced activation of NF-kappaB and sensitizes human prostate carcinoma DU145 cells to TNFalpha-induced apoptosis. Oncogene. 2002;21:1759
- . Proteasome inhibitor PS-341 down-regulates prostate-specific antigen (PSA) and induces growth arrest and apoptosis of androgen-dependent human prostate cancer LNCaP cells. Cancer Sci. 2004;95:271
- . Cyclooxygenases in hepatocellular carcinoma. World J Gastroenterol. 2006;12:5113
- . A pilot study of use of the cyclooxygenase-2 inhibitor celecoxib in recurrent prostate cancer after definitive radiation therapy or radical prostatectomy. BJU Int. 2004;93:275
- . The proteasome inhibitor bortezomib sensitizes cells to killing by death receptor ligand TRAIL via BH3-only proteins Bik and Bim. Mol Cancer Ther. 2005;4:443
- . MG-132 sensitizes TRAIL-resistant prostate cancer cells by activating c-Fos/c-Jun heterodimers and repressing c-FLIP(L). Cancer Res. 2007;67:2247
- Mutational analysis of Noxa gene in human cancers. APMIS. 2003;111:599
- Pharmacokinetics, biodistribution, and antitumor efficacy of a human glandular kallikrein 2 (hK2)-activated thapsigargin prodrug. Prostate. 2006;66:358
- . Mechanisms of resistance to TRAIL-induced apoptosis in cancer. Cancer Gene Ther. 2005;12:228
- . APO2 ligand/tumor necrosis factor-related apoptosis-inducing ligand in prostate cancer therapy. Front Biosci. 2006;11:1549
- The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces caspase-dependent and -independent apoptosis in acute myelogenous leukemia. Cancer Res. 2004;64:7927
- Synthetic triterpenoids cooperate with tumor necrosis factor-related apoptosis-inducing ligand to induce apoptosis of breast cancer cells. Cancer Res. 2005;65:4799
- . Epigenetics in human disease and prospects for epigenetic therapy. Nature. 2004;429:457
- . Mechanisms of cell death induced by histone deacetylase inhibitors in androgen receptor-positive prostate cancer cells. Mol Cancer Res. 2006;4:113
- In vivo and in vitro antitumor activity of butyroyloxymethyl-diethyl phosphate (AN-7), a histone deacetylase inhibitor, in human prostate cancer. Int J Cancer. 2005;116:226
- . SAHA-sensitized prostate cancer cells to TNFalpha-related apoptosis-inducing ligand (TRAIL): mechanisms leading to synergistic apoptosis. Int J Cancer. 2006;119:221
- . Lenalidomide and thalidomide: mechanisms of action—similarities and differences. Semin Hematol. 2005;42:S3
For another article on a related topic see page 2176.
Supported by Department of Defense Grant W81XWH-05-1-0080, National Institutes of Health Grant DK64062 and Howard Hughes Medical Institute/SPORE Grant 53000234-0006 to the Biomedical Research Support Program at Harvard Medical School (AFO).
PII: S0022-5347(07)01671-0
doi: 10.1016/j.juro.2007.06.039
© 2007 American Urological Association. Published by Elsevier Inc. All rights reserved.
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The Journal of Urology
Volume 178, Issue 5
, Pages 1846-1854
, November 2007

