The Journal of Urology
Volume 178, Issue 4 , Pages 1306-1310 , October 2007

The Significance of Positive Surgical Margin in Areas of Capsular Incision in Otherwise Organ Confined Disease at Radical Prostatectomy

  • Ai-Ying Chuang

      Affiliations

    • Department of Pathology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan
    • Affiliation of National Yang-Ming University, Taipei, Taiwan
    • Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland
    • ,
  • Matthew E. Nielsen

      Affiliations

    • Department of Urology, The Johns Hopkins Hospital, Baltimore, Maryland
    • ,
  • David J. Hernandez

      Affiliations

    • Department of Urology, The Johns Hopkins Hospital, Baltimore, Maryland
    • ,
  • Patrick C. Walsh

      Affiliations

    • Department of Urology, The Johns Hopkins Hospital, Baltimore, Maryland
    • ,
  • Jonathan I. Epstein

      Affiliations

    • Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland
    • Department of Urology, The Johns Hopkins Hospital, Baltimore, Maryland
    • Department of Oncology, The Johns Hopkins Hospital, Baltimore, Maryland
    • Corresponding Author InformationCorrespondence: The Johns Hopkins Hospital, The Weinberg Building, Room 2242, 401 N. Broadway St., Baltimore, Maryland 21231.

Received 22 February 2007

References 

  1. Ohori M, Wheeler TM, Kattan MW, Goto Y, Scardino PT. Prognostic significance of positive surgical margins in radical prostatectomy specimens. J Urol. 1995;154:1818
  2. Shuford MD, Cookson MS, Chang SS, Shintani AK, Tsiatis A, Smith JA, et al. Adverse prognostic significance of capsular incision with radical retropubic prostatectomy. J Urol. 2004;172:119
  3. Cheng L, Darson MF, Bergstralh EJ, Slezak J, Myers RP, Bostwick DG. Correlation of margin status and extraprostatic extension with progression of prostate carcinoma. Cancer. 1999;86:1775
  4. Boccon-Gibod L, Ravery V, Vordos D, Toublanc M, Delmas V, Boccon-Gibod L. Radical prostatectomy for prostate cancer: the perineal approach increases the risk of surgically induced positive margins and capsular incisions. J Urol. 1998;160:1383
  5. Barocas DA, Han M, Epstein JI, Chan DY, Trock BJ, Walsh PC, et al. Does capsular incision at radical retropubic prostatectomy affect disease-free survival in otherwise organ-confined prostate cancer?. Urology. 2001;58:746
  6. van den Ouden D, Bentvelsen FM, Boeve ER, Schroder FH. Positive margins after radical prostatectomy: correlation with local recurrence and distant progression. Br J Urol. 1993;72:489
  7. Rosen MA, Goldstone L, Lapin S, Wheeler T, Scardino PT. Frequency and location of extracapsular extension and positive surgical margins in radical prostatectomy specimens. J Urol. 1992;148:331
  8. Stamey TA, Villers AA, McNeal JE, Link PC, Freiha FS. Positive surgical margins at radical prostatectomy: importance of the apical dissection. J Urol. 1990;143:1166
  9. Watson RB, Civantos F, Soloway MS. Positive surgical margins with radical prostatectomy: detailed pathological analysis and prognosis. Urology. 1996;48:80
  10. Weldon VE, Tavel FR, Neuwirth H, Cohen R. Patterns of positive specimen margins and detectable prostate specific antigen after radical perineal prostatectomy. J Urol. 1995;153:1565
  11. Epstein JI. Incidence and significance of positive margins in radical prostatectomy specimens. Urol Clin North Am. 1996;23:651
  12. Epstein JI, Amin M, Boccon-Gibod L, Egevad L, Humphrey PA, Mikuz G, et al. Prognostic factors and reporting of prostate carcinoma in radical prostatectomy and pelvic lymphadenectomy specimens. Scand J Urol Nephrol. 2005;216(suppl.):34
  13. Ackerman DA, Barry JM, Wicklund RA, Olson N, Lowe BA. Analysis of risk factors associated with prostate cancer extension to the surgical margin and pelvic node metastasis at radical prostatectomy. J Urol. 1993;150:1845
  14. Blute ML, Bostwick DG, Bergstralh EJ, Slezak JM, Martin SK, Amling CL, et al. Anatomic site-specific positive margins in organ-confined prostate cancer and its impact on outcome after radical prostatectomy. Urology. 1997;50:733

 Nothing to disclose.

 Editor’s Note: This article is the second of 5 published in this issue for which category 1 CME credits can be earned. Instructions for obtaining credits are given with the questions on pages 1556 and 1557.

PII: S0022-5347(07)01430-9

doi: 10.1016/j.juro.2007.05.159

The Journal of Urology
Volume 178, Issue 4 , Pages 1306-1310 , October 2007

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