The Journal of Urology
Volume 178, Issue 2 , Pages 608-612 , August 2007

Uniform Testicular Maturation Arrest: A Unique Subset of Men With Nonobstructive Azoospermia

  • Andrew J. Hung
    • ,
  • Peggy King
    • ,
  • Peter N. Schlegel

      Affiliations

    • Corresponding Author InformationCorrespondence: Department of Urology, New York Presbyterian Hospital, Weill Medical College of Cornell University, 525 East 68th St. Starr 900, New York, New York 10021 (telephone: 212-746-5491; FAX: 212-746-8425).

Received 16 December 2006

References 

  1. Ferlin A, Arredi B, Foresta C. Genetic causes of male infertility. Reprod Toxicol. 2006;22:133
  2. Rucker GB, Mielnik A, King P, Goldstein M, Schlegel PN. Preoperative screening for genetic abnormalities in men with nonobstructive azoospermia before testicular sperm extraction. J Urol. 1998;160:2068
  3. Reijo R, Lee TY, Salo P, Alagappan R, Brown LG, Rosenberg M, et al. Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene. Nat Genet. 1995;10:383
  4. Ma K, Inglis JD, Sharkey A, Bickmore WA, Hill RE, Prosser EJ, et al. A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis. Cell. 1993;75:1287
  5. Vogt PH, Edelmann A, Kirsch S, Henegariu O, Hirschmann P, Kiesewetter F, et al. Human Y chromosome azoospermia factors (AZF) mapped to different subregions in Yq11. Hum Mol Genet. 1996;5:933
  6. Foresta C, Moro E, Ferlin A. Y chromosome microdeletions and alterations of spermatogeneis. Endocr Rev. 2001;22:226
  7. Chan PT, Schlegel PN. Nonobstructive azoospermia. Curr Opin Urol. 2000;10:617
  8. Su LM, Palermo GD, Goldstein M, Veeck LL, Rosenwaks Z, Schlegel PN. Testicular sperm extraction with intracytoplasmic sperm injection for nonobstrcutive azoospermia: testicular histology can predict success of sperm retrieval. J Urol. 1999;161:112
  9. Ishikawa T, Fujioka H, Fujisawa M. Clinical and hormonal findings in testicular maturation arrest. BJU Int. 2004;94:1314
  10. Schoor RA, Elhanbly S, Niederberger CS, Ross LS. The role of testicular biopsy in the modern management of male infertility. J Urol. 2002;167:197
  11. Sharlip ID, Jarow JP, Belker AM, Lipshultz LI, Sigman M, Thomas AJ, et al. Best practice policies for male infertility. Fertil Steril. 2002;77:873
  12. Raman JD, Schlegel PN. Aromatase inhibitors for male infertility. J Urol. 2002;167:624
  13. Schlegel PN, Palermo GD, Goldstein M, Menendez S, Zaninovic N, Veeck LL, et al. Testicular sperm extraction with intracytoplasmic sperm injection for nonosbructive azoospermia. Urology. 1997;49:435
  14. Ostad M, Liotta D, Ye Z, Schlegel PN. Testicular sperm extraction for nonobstructive azoospermia: results of a multibiopsy approach with optimized tissue dispersion. Urology. 1998;52:692
  15. Schlegel PN. Testicular sperm extraction: microdissection improves sperm yield with minimal tissue excision. Hum Reprod. 1999;14:131
  16. Palermo GD, Schlegel PN, Colombero LT, Zaninovic N, Moy F, Rosenwaks Z. Aggressive sperm immobilization prior to intracytoplasmic sperm injection with immature spermatozoa improves fertilization and pregnancy rates. Hum Reprod. 1996;11:1023
  17. Bannister LA, Schimenti JC. Homologous recombinational repair proteins in mouse meiosis. Cytogenet Genome Res. 2004;107:191
  18. Gonsalves J, Sun F, Schlegel PN, Turek PJ, Hopps CV, Greene C, et al. Defective recombination in infertile men. Hum Mol Genet. 2004;13:2875
  19. Hopps CV, Mielnik A, Goldstein M, Palermo GD, Rosenwaks Z, Schlegel PN. Detection of sperm in men with Y chromosome microdeletions of the AZFa, AZFb and AZFc regions. Hum Reprod. 2003;18:1660
  20. Ramasamy R, Schlegel PN. Microdissection testicular sperm extraction: effect of prior biopsy on success of sperm retrieval. J Urol. 2007;177:1447

 Study received Internal Review Board approval.

PII: S0022-5347(07)00773-2

doi: 10.1016/j.juro.2007.03.125

The Journal of Urology
Volume 178, Issue 2 , Pages 608-612 , August 2007

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