The Journal of Urology
Volume 177, Issue 5 , Pages 1736-1740 , May 2007

Early Prostate Cancer Antigen Expression in Predicting Presence of Prostate Cancer in Men With Histologically Negative Biopsies

  • D.E. Hansel

      Affiliations

    • Department of Pathology, at The Johns Hopkins University, Baltimore, Maryland
    • ,
  • A.M. DeMarzo

      Affiliations

    • Department of Pathology, at The Johns Hopkins University, Baltimore, Maryland
    • Department of Urology, at The Johns Hopkins University, Baltimore, Maryland
    • Financial interest and/or other relationship with Genomic Health and GlaxoSmithKline.
    • ,
  • E.A. Platz

      Affiliations

    • Department of Urology, at The Johns Hopkins University, Baltimore, Maryland
    • Department of Oncology, at The Johns Hopkins University, Baltimore, Maryland
    • Bloomberg School of Public Health, at The Johns Hopkins University, Baltimore, Maryland
    • ,
  • S. Jadallah

      Affiliations

    • Department of Pathology, at The Johns Hopkins University, Baltimore, Maryland
    • ,
  • J. Hicks

      Affiliations

    • Department of Pathology, at The Johns Hopkins University, Baltimore, Maryland
    • ,
  • J.I. Epstein

      Affiliations

    • Department of Pathology, at The Johns Hopkins University, Baltimore, Maryland
    • Department of Urology, at The Johns Hopkins University, Baltimore, Maryland
    • Department of Oncology, at The Johns Hopkins University, Baltimore, Maryland
    • ,
  • A.W. Partin

      Affiliations

    • Department of Pathology, at The Johns Hopkins University, Baltimore, Maryland
    • Department of Urology, at The Johns Hopkins University, Baltimore, Maryland
    • Department of Oncology, at The Johns Hopkins University, Baltimore, Maryland
    • ,
  • G.J. Netto

      Affiliations

    • Department of Pathology, at The Johns Hopkins University, Baltimore, Maryland
    • Corresponding Author InformationCorrespondence: Johns Hopkins University, 401 N. Broadway/2242 Weinberg Building, Baltimore, Maryland 21231.

Received 16 August 2006

References 

  1. Paul B, Dhir R, Landsittel D, Hitchens MR, Getzenberg RH. Detection of prostate cancer with a blood-based assay for early prostate cancer antigen. Cancer Res. 2005;65:4097
  2. Dhir R, Vietmeier B, Arlotti J, Acquafondata M, Landsittel D, Masterson R, et al. Early identification of individuals with prostate cancer in negative biopsies. J Urol. 2004;171:1419
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  4. Partin AW, Getzenberg RH, Carmichael MJ, Vindivich D, Yoo J, Epstein JI, et al. Nuclear matrix protein patterns in human benign prostatic hyperplasia and prostate cancer. Cancer Res. 1993;53:744
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  12. Hong YM, Lai FC, Chon CH, McNeal JE, Presti JC. Impact of prior biopsy scheme on pathologic features of cancers detected on repeat biopsies. Urol Oncol. 2004;22:7
  13. Park SJ, Miyake H, Hara I, Eto H. Predictors of prostate cancer on repeat transrectal ultrasound-guided systematic prostate biopsy. Int J Urol. 2003;10:68
  14. Mian BM, Naya Y, Okihara K, Vakar-Lopez F, Troncoso P, Babaian RJ. Predictors of cancer in repeat extended multisite prostate biopsy in men with previous negative extended multisite biopsy. Urology. 2002;60:836
  15. Chan TY, Epstein JI. Follow-up of atypical prostate needle biopsies suspicious for cancer. Urology. 1999;53:351
  16. Epstein JI, Herawi M. Prostate needle biopsies containing prostatic intraepithelial neoplasia or atypical foci suspicious for carcinoma: implications for patient care. J Urol. 2006;175:820
  17. Cheville JC, Reznicek MJ, Bostwick DG. The focus of “atypical glands, suspicious for malignancy” in prostatic needle biopsy specimens: incidence, histologic features, and clinical follow-up of cases diagnosed in a community practice. Am J Clin Pathol. 1997;108:633
  18. Lakshmanan Y, Subong EN, Partin AW. Differential nuclear matrix protein expression in prostate cancers: correlation with pathologic stage. J Urol. 1998;159:1354
  19. Barboro P, Rubagotti A, Boccardo F, Carnemolla B, Darrigo C, Patrone E, et al. Nuclear matrix protein expression in prostate cancer: possible prognostic and diagnostic applications. Anticancer Res. 2005;25:3999
  20. Jacobs TW, Prioleau JE, Stillman IE, Schnitt SJ. Loss of tumor marker-immunostaining intensity on stored paraffin slides of breast cancer. J Natl Cancer Inst. 1996;88:1054

PII: S0022-5347(07)00013-4

doi: 10.1016/j.juro.2007.01.013

The Journal of Urology
Volume 177, Issue 5 , Pages 1736-1740 , May 2007

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