The Journal of Urology
Volume 177, Issue 3 , Pages 972-975 , March 2007

Verapamil Versus Saline in Electromotive Drug Administration for Peyronie’s Disease: A Double-Blind, Placebo Controlled Trial

  • Jason M. Greenfield
    • ,
  • Sneha J. Shah
    • ,
  • Laurence A. Levine

      Affiliations

    • Corresponding Author InformationCorrespondence: 1725 West Harrison St., PB Suite 352, Chicago, Illinois 60612 (telephone: 312-563-5000; FAX: 312-563-5007).
    • Financial interest and/or other relationship with Pfizer, Lilly-ICOS, Bayer-GlaxoSmithKline, Auxilium, American Medical Systems and Augusta Medical Systems.

Received 19 April 2006

References 

  1. Roth M, Eickelberg O, Kohler E, Erne P, Block LH. Ca2+ channel blockers modulate metabolism of collagens within the extracellular matrix. Proc Natl Acad Sci U S A. 1996;93:5478
  2. Bronaugh RL, Maibach HIE. Percutaneous Absorption: Mechanisms—Methodology—Drug Delivery. New York: Marcel Dekker; 1989;
  3. Higuchi WI, Li SK, Ghanem AH, Zhu H, Song Y. Mechanistic aspects of iontophoresis in human epidermal membrane. J Control Release. 1999;62:13
  4. Levine LA, Estrada CR, Shou W, Cole A. Tunica albuginea tissue analysis after electromotive drug administration. J Urol. 2003;169:1775
  5. DiStasi SM, Giannantoni A, Capelli G, Jannini EA, Virgili G, Storti L, et al. Transdermal electromotive administration of verapamil and dexamethasone for Peyronie’s disease. BJU Int. 2003;91:825
  6. DiStasi SM, Giannantoni A, Stephen RL, Capelli G, Giurioli A, Jannini EA, et al. A prospective, randomized study using transdermal electromotive administration of verapamil and dexamethasone for Peyronie’s disease. J Urol. 2004;171:1605
  7. Althof SE, Corty EW, Levine SB, Levine F, Burnett AL, McVary K, et al. EDITS: development of questionnaires for evaluating satisfaction with treatments for erectile dysfunction. Urology. 1999;53:793
  8. Levine LA, Goldman KE, Greenfield JM. Experience with intraplaque injection of verapamil for Peyronie’s disease. J Urol. 2002;168:621
  9. Martin DJ, Badwan K, Parker M, Mulhall JP. Transdermal application of verapamil gel to the penile shaft fails to infiltrate the tunica albuginea. J Urol. 2002;168:2483
  10. Riedl CR, Plas E, Engelhardt P, Daha K, Pfluger H. Iontophoresis for treatment of Peyronie’s disease. J Urol. 2000;163:95
  11. Montorsi F, Salonia A, Guazzoni G, Barbieri L, Colombo R, Brausi M, et al. Transdermal electromotive multi-drug administration for Peyronie’s disease: preliminary results. J Androl. 2000;21:85
  12. Stephens, R: Personal communication. Mirandola, Italy: Physion Co.
  13. Kadioglu A, Tefekli A, Erol H, Oktar T, Tunc M, Tellaloglu S. A retrospective review of 307 men with Peyronie’s disease. J Urol. 2002;168:1075
  14. Mulhall JP, Parker M, Guhring P. The natural history of Peyronie’s disease. 2004;Presented at biennial meeting of International Society of Sexual Medicine, Buenos Aires, Argentina, October 17–21
  15. Ojingwa JC, Isserhoff RR. Electrical stimulation of wound healing. J Invest Dermatol. 2003;121:1
  16. Levine LA, Greenfield JM. Establishing a standardized evaluation of the man with Peyronie’s disease. Int J Impot Res. 2003;15:S103

 Study received Institutional Review Board approval.

PII: S0022-5347(06)02735-2

doi: 10.1016/j.juro.2006.10.065

The Journal of Urology
Volume 177, Issue 3 , Pages 972-975 , March 2007

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