The Journal of Urology
Volume 177, Issue 3 , Pages 921-924 , March 2007

The Effect of Androgen Deprivation Therapy on Periodontal Disease in Men With Prostate Cancer

  • Pouran Famili

      Affiliations

    • Department of Periodontics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
    • Corresponding Author InformationCorrespondence: Department of Periodontics, School of Dental Medicine, University of Pittsburgh, Room B94, Salk Hall, 3501 Terrace St., Pittsburgh, Pennsylvania 15261 (telephone: 412-648-8598; FAX: 412-648-8594).
    • ,
  • Jane A. Cauley

      Affiliations

    • Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania
    • ,
  • Susan L. Greenspan

      Affiliations

    • Graduate School of Public Health and Osteoporosis Prevention and Treatment Center, Division of Endocrinology and Metabolism, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania

Received 26 April 2006

References 

  1. Ross RW, Small EJ. Osteoporosis in men treated with androgen deprivation therapy for prostate cancer. J Urol. 2002;167:1952
  2. Wei JT, Gross M, Jaffe CA, Gravlin K, Lahie M, Faerber GJ, et al. Androgen deprivation therapy for prostate cancer results in significant loss of bone density. Urology. 1999;54:607
  3. Diamond T, Campbell J, Bryant C, Lynch W. The effect of combined androgen blockade on bone turnover and bone mineral densities in men treated for prostate carcinoma: longitudinal evaluation and response to intermittent cyclic etidronate therapy. Cancer. 1998;83:1561
  4. Morote J, Martinez E, Trilla E, Esquena S, Abascal JM, Encabo G, et al. Osteoporosis during continuous androgen deprivation: Influence of the modality and length of treatment. Eur Urol. 2003;44:661
  5. Deng JH, Yang LP, Wang LS, Zhou DF. Effect of androgen-deprivation therapy on bone mineral density in prostate cancer patients. Asian J Androl. 2004;6:75
  6. Higano CS. Management of bone loss in men with prostate cancer. J Urol, part 2. 2003;170:S59
  7. Seeman E. Osteoporosis in men. Baillieres Clin Rheumatol. 1997;11:613
  8. Seeman E, Eisman JA. Treatment of osteoporosis: why, whom, when and how to treat (The single most important consideration is the individual’s absolute risk of fracture). Med J Aust. 2004;180:298
  9. Seeman E, Melton LJ, O’Fallon WM, Riggs BL. Risk factors for spinal osteoporosis in men. Am J Med. 1983;75:977
  10. Rees TD. A profile of the patient with periodontal disease?. Periodontol 2000. 2003;32:9
  11. Albandar JM, Ram TE. Global epidemiology of periodontal diseases: an overview. Periodontol 2000. 2002;29:7
  12. Slots J. Update of general health risk of periodontal disease. Int Dental J. 2003;3(suppl.):200
  13. Nunn ME. Understanding the etiology of periodontitis: an overview of periodontal risk factors. Periodontol 2000. 2003;32:11
  14. Genco RJ. Current view of risk factors for periodontal disease. J Periodontol. 1996;67:1041
  15. Weyant RJ, Pearlstein ME, Churak AP, Forrest K, Famili P, Cauley JA. The association between osteopenia and periodontal attachment loss in older women. J Periodontol. 1999;70:982
  16. Eggert FM, McLeod MH, Flowerdew G. Effects of smoking and treatment status on periodontal bacteria: Evidence that smoking influences control of periodontal bacteria at the mucosal surface of the gingival crevice. J Periodontol. 2001;72:1210
  17. Rashid MH, Chaudhary UB. Intermittent androgen deprivation therapy for prostate cancer. Oncologist. 2004;9:295
  18. Jeffcoat MK. Osteoporosis: a possible modifying factor in oral bone loss. Ann Periodontol. 1998;3:312
  19. Kribbs PJ. Comparison of mandibular bone in normal and osteoporotic women. J Prosthet Dentistry. 1990;63:218

 Study was performed with the full prior regulatory approval of the University of Pittsburgh Institutional Review (IRB No. 030761) in 2003.Supported by the Osteoporosis Prevention and Treatment Center at the University of Pittsburgh, which receives support through National Institutes of Health (K24 DK 062895-01) and the General Clinical Research Center of the University of Pittsburgh Medical Center (M01-RR0056).

PII: S0022-5347(06)02733-9

doi: 10.1016/j.juro.2006.10.067

The Journal of Urology
Volume 177, Issue 3 , Pages 921-924 , March 2007

Article Tools