The Journal of Urology
Volume 177, Issue 2 , Pages 639-643 , February 2007

High Dose Zinc Increases Hospital Admissions Due to Genitourinary Complications

  • Aaron R. Johnson

      Affiliations

    • Department of Surgery (Division of Urology), University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
    • ,
  • Alejandro Munoz

      Affiliations

    • Department of Surgery (Division of Urology), University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
    • ,
  • Justin L. Gottlieb

      Affiliations

    • Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
    • ,
  • David F. Jarrard

      Affiliations

    • Department of Surgery (Division of Urology), University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
    • University of Wisconsin Comprehensive Cancer Center, Madison, Wisconsin
    • Corresponding Author InformationCorrespondence: K6/527 University of Wisconsin Clinical Science Center, 600 Highland Ave., Madison, Wisconsin 53792 (telephone: 608-263-9534; FAX: 608-263-0454).

Received 24 March 2006

References 

  1. Briefel RR, Bialostosky K, Kennedy-Stephenson J, McDowell MA, Ervin RB, Wright JD. Zinc intake of the U.S. population: findings from the third National Health and Nutrition Examination Survey, 1988–1994. J Nutr. 2000;130:1367S
  2. Prasad AS. Clinical, endocrinologic, and biochemical effects of zinc deficiency. Spec Top Endocrinol Metab. 1985;7:45
  3. Zaichick VY, Sviridova TV, Zaichick SV. Zinc in the human prostate gland: normal, hyperplastic and cancerous. Int Urol Nephrol. 1997;29:565
  4. Moyad MA. Zinc for prostate disease and other conditions: a little evidence, a lot of hype, and a significant potential problem. Urol Nurs. 2004;24:49
  5. Lagiou P, Wuu J, Trichopoulou A, Hsieh CC, Adami HO, Trichopoulos D. Diet and benign prostatic hyperplasia: a study in Greece. Urology. 1999;54:284
  6. Liang JY, Liu YY, Zou J, Franklin RB, Costello LC, Feng P. Inhibitory effect of zinc on human prostatic carcinoma cell growth. Prostate. 1999;40:200
  7. Leitzmann MF, Stampfer MJ, Wu K, Colditz GA, Willett WC, Giovannucci EL. Zinc supplement use and risk of prostate cancer. J Natl Cancer Inst. 2003;95:1004
  8. Nemoto K, Kondo Y, Himeno S, Suzuki Y, Hara S, Akimoto M, et al. Modulation of telomerase activity by zinc in human prostatic and renal cancer cells. Biochem Pharmacol. 2000;59:401
  9. Jarrard DF. Does zinc supplementation increase the risk of prostate cancer?. Arch Ophthalmol. 2005;123:102
  10. Costello LC, Franklin RB, Feng P, Tan M. Re: Zinc supplement use and risk of prostate cancer. J Natl Cancer Inst. 2004;96:239
  11. Sutor DJ, Wooley SE. Growth studies of calcium oxalate in the presence of various compounds and ions. II. Br J Urol. 1970;42:296
  12. Meyer JL, Angino EE. The role of trace metals in calcium urolithiasis. Invest Urol. 1977;14:347
  13. Ozgurtas T, Yakut G, Gulec M, Serdar M, Kutluay T. Role of urinary zinc and copper on calcium oxalate stone formation. Urol Int. 2004;72:233
  14. Chavakis T, May AE, Preissner KT, Kanse SM. Molecular mechanisms of zinc-dependent leukocyte adhesion involving the urokinase receptor and beta2-integrins. Blood. 1999;93:2976
  15. Rajagopalan S, Winter CC, Wagtmann N, Long EO. The Ig-related killer cell inhibitory receptor binds zinc and requires zinc for recognition of HLA-C on target cells. J Immunol. 1995;155:4143
  16. Chandra RK. Excessive intake of zinc impairs immune responses. JAMA. 1984;252:1443
  17. Rink L, Gabriel P. Zinc and the immune system. Proc Nutr Soc. 2000;59:541
  18. Age-related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol. 2001;119:1417
  19. Duchateau J, Delespesse G, Vereecke P. Influence of oral zinc supplementation on the lymphocyte response to mitogens of normal subjects. Am J Clin Nutr. 1981;34:88
  20. Clemons TE, Kurinij N, Sperduto RD. Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13. Arch Ophthalmol. 2004;122:716
  21. Costello LC, Franklin RB. Novel role of zinc in the regulation of prostate citrate metabolism and its implications in prostate cancer. Prostate. 1998;35:285
  22. Samman S, Roberts DC. The effect of zinc supplements on lipoproteins and copper status. Atherosclerosis. 1988;70:247
  23. Kristal AR, Stanford JL, Cohen JH, Wicklund K, Patterson RE. Vitamin and mineral supplement use is associated with reduced risk of prostate cancer. Cancer Epidemiol Biomarkers Prev. 1999;8:887
  24. Albanes D, Heinonen OP, Huttunen JK, Taylor PR, Virtamo J, Edwards BK, et al. Effects of alpha-tocopherol and beta-carotene supplements on cancer incidence in the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study. Am J Clin Nutr. 1995;62:1427S

PII: S0022-5347(06)02494-3

doi: 10.1016/j.juro.2006.09.047

The Journal of Urology
Volume 177, Issue 2 , Pages 639-643 , February 2007

Article Tools

* Image Usage & Resolution