The Journal of Urology
Volume 177, Issue 1 , Pages 386-389 , January 2007

Effect of Acute Dapoxetine Administration on the Pudendal Motoneuron Reflex in Anesthetized Rats: Comparison With Paroxetine

  • F. Giuliano

      Affiliations

    • Pelvipharm Laboratories, Gif-sur-Yvette, France
    • Neuro-Urology Unit, Department of Neurological Rehabilitation, Raymond Poincaré Hospital AP-HP, Garches, France
    • Financial interest and/or other relationship with Solway, Pfizer, Lilly, Sanofi, Aventis, Roche, Johnson & Johnson, Serini and GlaxoSmithKline.
    • Corresponding Author InformationCorrespondence: Neuro-Urology Unit, Department of Neurological Rehabilitation, Raymond Poincaré Hospital, 104 Bd. Raymond Poincaré, 92380 Garches, France (telephone: +33 147107072; FAX: +33 147107615).
  • ,
  • J. Bernabé

      Affiliations

    • Pelvipharm Laboratories, Gif-sur-Yvette, France
  • ,
  • P. Gengo

      Affiliations

    • Alza Corp., Mountain View, California
  • ,
  • L. Alexandre

      Affiliations

    • Pelvipharm Laboratories, Gif-sur-Yvette, France
  • ,
  • P. Clément

      Affiliations

    • Pelvipharm Laboratories, Gif-sur-Yvette, France

Received 18 November 2005

References 

  1. Lewis RW, Fugl-Meyer KS, Bosch R, Fugl-Meyer AR, Laumann EO, Lissa E, et al. Definitions, classifications and epidemiology of sexual dysfunction in sexual medicine. In:  Lue TF,  Basson R,  Rosen R,  Giuliano F,  Khoury S,  Montorsi F editor. Sexual Dysfunctions in Men and Women, 2nd International Consultation on Sexual Dysfunctions. Oxford: Health Publication Ltd; 2004;p. 37–72
  2. Waldinger MD, Hengeveld MW, Zwinderman AH. Paroxetine treatment of premature ejaculation: a double-blind, randomized, placebo-controlled study. Am J Psychiatry. 2004;151:1377
  3. Kara H, Aydin S, Yucel M, Agargun MY, Odabas O, Yilmaz Y. The efficacy of fluoxetine in the treatment of premature ejaculation: a double-blind placebo controlled study. J Urol. 1996;156:1631
  4. Waldinger MD, Hengeveld MW, Zwinderman AH, Olivier B. Effect of SSRI antidepressants on ejaculation: a double-blind, randomized, placebo-controlled study with fluoxetine, fluvoxamine, paroxetine, and sertraline. J Clin Psychopharmacol. 1998;18:274
  5. McMahon CG, Touma K. Treatment of premature ejaculation with paroxetine hydrochloride as needed: 2 single-blind placebo controlled crossover studies. J Urol. 1999;161:1826
  6. Abdel-Hamid IA, El Naggar EA, El Gilany AH. Assessment of as needed use of pharmacotherapy and the pause-squeeze technique in premature ejaculation. Int J Impot Res. 2001;13:41
  7. Waldinger MD, Zwinderman AH, Olivier B. On-demand treatment of premature ejaculation with clomipramine and paroxetine: a randomized, double-blind fixed-dose study with stopwatch assessment. Eur Urol. 2004;46:510
  8. Cantor JM, Binik YM, Pfaus JG. Chronic fluoxetine inhibits sexual behavior in the male rat: reversal with oxytocin. Psychopharmacol. 1999;144:355
  9. Waldinger MD, van De Plasqq A, Pattij T, van Oorschot R, Coolen LM, Veening JG, et al. The selective serotonin re-uptake inhibitors fluvoxamine and paroxetine differ in sexual inhibitory effects after chronic treatment. Psychopharmacol. 2002;160:283
  10. Yells DP, Prendergast MA, Hendricks SE, Nakamura M. Fluoxetine-induced inhibition of male rat copulatory behavior: modification by lesions of the nucleus paragigantocellularis. Pharmacol Biochem Behav. 1994;49:121
  11. Mos J, Mollet I, Tolboom J, Waldinger MD, Olivier B. A comparison of the effects of different serotonin reuptake blockers on sexual behaviour of the male rat. Eur Neuropsychopharmacol. 1999;9:123
  12. Gil-Vernet JM, Alvarez-Vijande R, Gil-Vernet A, Gil-Vernet JM. Ejaculation in men: a dynamic endorectal ultrasonographical study. Br J Urol. 1994;73:442
  13. Gerstenberg TC, Levin RJ, Wagner G. Erection and ejaculation in man (Assessment of the electromyographic activity of the bulbocavernosus and ischiocavernosus muscles). Br J Urol. 1990;65:395
  14. Truit WA, Coolen LM. Identification of a potential ejaculation generator in the spinal cord. Science. 2002;297:1566
  15. Johnson RD, Hubscher CH. Brainstem microstimulation differentially inhibits pudendal motoneuron reflex inputs. Neuroreport. 1998;9:341
  16. Brackett NL, Ferrell SM, Aballa TC, Amador MJ, Padron OF, Sonksen J, et al. An analysis of 653 trials of penile vibratory stimulation in men with spinal cord injury. J Urol. 1998;159:1931
  17. Lagoda G, Muschamp JW, Vigdorchik A, Hull EM. A nitric oxide synthesis inhibitor in the medial preoptic area inhibits copulation and stimulus sensitization in male rats. Behav Neurosci. 2004;118:1317
  18. Maggi CA, Meli A. Suitability of urethane anesthesia for physiopharmacological investigations in various systems. Part 1: general considerations. Experientia. 1986;42:109
  19. Chan-Palay V. Morphological correlates for transmitter synthesis, transport, release, uptake and catabolism: a study of serotonin neurons in the nucleus paragigantocellularis lateralis. In:  Fonnum F editors. Amino Acids as Chemical Transmitters. New York: Plenum Press; 1978;p. 1–29Proceedings of the NATO Advanced Study Institute on Amino Acids as Chemical Transmitters held in Oslo, Norway, August 14–21, 1977.
  20. Marson L, McKenna KE. A role for 5-hydroxytryptamine in descending inhibition of spinal sexual reflexes. Exp Brain Res. 1992;88:313
  21. Giuliano F, Clement P. Physiology of ejaculation: emphasis on serotonergic control. Eur Urol. 2005;48:408
  22. Pryor JL, Althof SE, Steidle C, Rosen RC, Hellstrom WJ, Shabsigh R, et al. Efficacy and tolerability of dapoxetine in treatment of premature ejaculation: an integrated analysis of two double-blind, randomised controlled trials. Lancet. 2006;368:929

 Study was done in accordance with the European Communities Council Directives (86/609/EEC) on the use of laboratory animals.Supported by an unrestricted grant from Johnson & Johnson.

PII: S0022-5347(06)02202-6

doi: 10.1016/j.juro.2006.08.079

The Journal of Urology
Volume 177, Issue 1 , Pages 386-389 , January 2007