The Journal of Urology
Volume 177, Issue 1 , Pages 31-38 , January 2007

The Role of Randall’s Plaques in the Pathogenesis of Calcium Stones

  • Brian R. Matlaga

      Affiliations

    • Current address: James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287.
    • ,
  • Fredric L. Coe

      Affiliations

    • Financial interest and/or other relationship with LithoLink.
    • ,
  • Andrew P. Evan
    • ,
  • James E. Lingeman

      Affiliations

    • Corresponding Author InformationCorrespondence: Methodist Hospital Institute for Kidney Stone Disease, 1801 North Senate Blvd., Suite 220, Indianapolis, Indiana 46202 (telephone: 317-962-2485; FAX: 317-962-2893).
    • Financial interest and/or other relationship with Lumenis, Boston Scientific, Olympus and Karl Storz.

Received 5 December 2005

References 

  1. Stamatelou KK, Francis ME, Jones CA, Nyberg LM, Curhan GC. Time trends in reported prevalence of kidney stones in the United States: 1976–1994. Kidney Int. 2003;63:1817
  2. Pearle MS, Calhoun EA, Curhan GC. Urologic diseases in America project: urolithiasis. J Urol. 2005;173:848
  3. Matlaga BR, Assimos DG. Changing indications of open stone surgery. Urology. 2002;59:490
  4. Hess B, Kok DJ. Nucleation, growth, and aggregation of stone-forming crystals. In:  Coe FL,  Favus MJ,  Pak CYC,  Parks JH,  Preminger GM editor. Kidney Stones: Medical and Surgical Management. Philadelphia: Lippincott-Raven; 1996;p. 3–32
  5. Randall A. Papillary pathology as a precursor of primary renal calculus. J Urol. 1940;44:580
  6. Kuo RL, Lingeman JE, Evan AP, Paterson RF, Bledsoe SB, Kim SC, et al. Endoscopic renal papillary biopsies: a tissue retrieval technique for histological studies in patients with nephrolithiasis. J Urol. 2003;170:2186
  7. Evan AP, Lingeman JE, Coe FL, Parks JH, Bledsoe SB, Shao Y, et al. Randall’s plaque of patients with nephrolithiasis begins in basement membranes of thin loops of Henle. J Clin Invest. 2003;111:607
  8. Coe FL, Parks JH, Asplin JR. The pathogenesis and treatment of kidney stones. N Engl J Med. 1992;327:1141
  9. Kuo RL, Lingeman JE, Evan AP, Paterson RF, Parks JH, Bledsoe SB, et al. Urine calcium and volume predict coverage of renal papilla by Randall’s plaque. Kidney Int. 2003;64:2150
  10. Evan AP, Coe FL, Rittling SR, Bledsoe SB, Shao Y, Lingeman JE, et al. Apatite plaque particles in inner medulla of kidneys of calcium oxalate stone formers: osteopontin localization. Kidney Int. 2005;68:145
  11. Kim SC, Coe FL, Tinmouth WW, Kuo RL, Paterson RF, Parks JH, et al. Stone formation is proportional to papillary surface coverage by Randall’s plaque. J Urol. 2005;173:117
  12. Matlaga BR, Williams JC, Kim SC, Kuo RL, Evan AP, Bledsoe SB, et al. Endoscopic evidence of calculus attachment to Randall’s plaque. J Urol. 2006;175:1720
  13. Parks JH, Worcester EM, Coe FL, Evan AP, Lingeman JE. Clinical implications of abundant calcium phosphate in routinely analyzed kidney stones. Kidney Int. 2004;66:777
  14. Mandel N, Mandel I, Fryjoff K, Rejniak T, Mandel G. Conversion of calcium oxalate to calcium phosphate with recurrent stone episodes. J Urol. 2003;169:2026
  15. Evan AP, Lingeman JE, Coe FL, Shao Y, Parks JH, Bledsoe SB, et al. Crystal-associated nephropathy in patients with brushite nephrolithiasis. Kidney Int. 2005;67:576
  16. Finlayson B, Reid F. The expectation of free and fixed particles in urinary stone disease. Invest Urol. 1978;15:442
  17. Khan SR, Cockrell CA, Finlayson B, Hackett RL. Crystal retention by injured urothelium of the rat urinary bladder. J Urol. 1984;132:153
  18. Khan SR, Byer KJ, Thamilselvan S, Hackett RL, McCormack WT, Benson NA, et al. Crystal-cell interaction and apoptosis in oxalate-associated injury of renal epithelial cells. J Am Soc Nephrol suppl. 1999;10:S457
  19. Stoller ML, Meng MV, Abrahams HM, Kane JP. The primary stone event: a new hypothesis involving a vascular etiology. J Urol. 2004;171:1920

 Supported by National Institutes of Health Grants PO1 DK56788 and PO1 DK43881, and an American Foundation for Urologic Diseases Scholarship (BRM).

PII: S0022-5347(06)02172-0

doi: 10.1016/j.juro.2006.08.088

The Journal of Urology
Volume 177, Issue 1 , Pages 31-38 , January 2007

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