The Journal of Urology
Volume 176, Issue 4 , Pages 1648-1653 , October 2006

The Role of Serotonin (5-Hydroxytryptamine1A and 1B) Receptors in Prostate Cancer Cell Proliferation

  • Emad J. Siddiqui

      Affiliations

    • Departments of Urology and Clinical Biochemistry, Royal Free Hospital and University College Medical School, University College, London, United Kingdom
    • Corresponding Author InformationCorrespondence: Department of Clinical Biochemistry, 1st Floor, Royal Free Hospital and University College Medical School, University College London, Pond St., Hampstead, London NW3 2QG, United Kingdom (telephone: 00-44-7870600495; FAX: 00-44-2078302235)
    • ,
  • Majid Shabbir

      Affiliations

    • Departments of Urology and Clinical Biochemistry, Royal Free Hospital and University College Medical School, University College, London, United Kingdom
    • ,
  • Dimitri P. Mikhailidis

      Affiliations

    • Departments of Urology and Clinical Biochemistry, Royal Free Hospital and University College Medical School, University College, London, United Kingdom
    • ,
  • Cecil S. Thompson

      Affiliations

    • Departments of Urology and Clinical Biochemistry, Royal Free Hospital and University College Medical School, University College, London, United Kingdom
    • ,
  • Faiz H. Mumtaz

      Affiliations

    • Departments of Urology and Clinical Biochemistry, Royal Free Hospital and University College Medical School, University College, London, United Kingdom
    • Department of Urology, Barnet and Chase Farm Hospitals, London, United Kingdom

Received 19 July 2005

References 

  1. di Sant’Agnese PA . Neuroendocrine cells of the prostate and neuroendocrine differentiation in prostatic carcinoma (a review of morphologic aspects) . Urology . 1998;51:121
  2. Siddiqui EJ , Thompson CS , Mikhailidis DP , Mumtaz FH . The role of serotonin in tumour growth . (review) Oncol Rep . 2005;14:1593
  3. Silvestris N , Leone B , Numico G , Lorusso V , De Lena M . Present status and perspectives in the treatment of hormone-refractory prostate cancer . Oncology . 2005;69:273
  4. Takuwa N , Ganz M , Takuwa Y , Sterzel RB , Rasmussen H . Studies of the mitogenic effect of serotonin in rat renal mesangial cells . Am J Physiol . 1989;257:F431
  5. Yazaki T , Inage H , Iizumi T , Koyama A , Kanoh S , Koiso K , et al.   Studies on platelet function in patients with prostatic cancer. Preliminary report . Urology . 1987;30:60
  6. Dey RD , Hoffpauir J . Ultrastructural immunocytochemical localization of 5-hydroxytryptamine in gastric enterochromaffin cells . J Histochem Cytochem . 1984;32:661
  7. Ishizuka J , Beauchamp RD , Townsend CM , Greeley GH , Thompson JC . Receptor-mediated autocrine growth-stimulatory effect of 5-hydroxytryptamine on cultured human pancreatic carcinoid cells . J Cell Physiol . 1992;150:1
  8. Cattaneo MG , Fesce R , Vicentini LM . Mitogenic effect of serotonin in human small cell lung carcinoma cells via both 5-HT1A and 5-HT1D receptors . Eur J Pharmacol . 1995;291:209
  9. Tutton PJ , Barkla DH . Influence of inhibitors of serotonin uptake on intestinal epithelium and colorectal carcinomas . Br J Cancer . 1982;46:260
  10. Hoyer D , Clarke DE , Fozard JR , Hartig PR , Martin GR , Mylecharane EJ , et al.   International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin) . Pharmacol Rev . 1994;46:157
  11. Abdul M , Anezinis PE , Logothetis CJ , Hoosein NM . Growth inhibition of human prostatic carcinoma cell lines by serotonin antagonists . Anticancer Res . 1994;14:1215
  12. Abdul M , Logothetis CJ , Hoosein NM . Growth-inhibitory effects of serotonin uptake inhibitors on human prostate carcinoma cell lines . J Urol . 1995;154:247
  13. Dizeyi N , Bjartell A , Nilsson E , Hansson J , Gadaleanu V , Cross N , et al.   Expression of serotonin receptors and role of serotonin in human prostate cancer tissue and cell lines . Prostate . 2004;59:328
  14. Jiborn T , Bjartell A , Abrahamsson PA . Neuroendocrine differentiation in prostatic carcinoma during hormonal treatment . Urology . 1998;51:585
  15. Fanburg BL , Lee SL . A new role for an old molecule (serotonin as a mitogen) . Am J Physiol . 1997;272:L795
  16. Fenrick R , Pou C , Beliveau M , Fargin A . The human 5-hydroxytryptamine 1A receptor differentially modulates phospholipase C and adenylyl cyclase activities . Gen Pharmacol . 1996;27:263
  17. Strother JM , Beer TM , Dreicer R . Novel cytotoxic and biological agents for prostate cancer (where will the money be in 2005?) . Eur J Cancer . 2005;41:954
  18. Robertson CN , Roberson KM , Padilla GM , O’Brien ET , Cook JM , Kim CS , et al.   Induction of apoptosis by diethylstilbestrol in hormone-insensitive prostate cancer cells . J Natl Cancer Inst . 1996;88:908
  19. Siddiqui EJ , Shabbir M , Thompson CS , Mumtaz FH , Mikhailidis DP . Growth inhibitory effect of doxazosin on prostate and bladder cancer cells . Is the serotonin receptor pathway involved? Anticancer Res . 2005;25:4281
  20. Khan MA , Thompson CS , Dashwood MR , Mumtaz FH , Mikhailidis DP , Morgan RJ . Doxazosin modifies serotonin-mediated rabbit urinary bladder contraction. Potential clinical relevance . Urol Res . 2000;28:116

PII: S0022-5347(06)01534-5

doi: 10.1016/j.juro.2006.06.087

The Journal of Urology
Volume 176, Issue 4 , Pages 1648-1653 , October 2006

Article Tools

* Image Usage & Resolution