The Journal of Urology
Volume 176, Issue 4 , Pages 1636-1641 , October 2006

Leptin Promotes Invasiveness of Murine Renal Cancer Cells Via Extracellular Signal-Regulated Kinases and Rho Dependent Pathway

  • Akio Horiguchi

      Affiliations

    • Department of Urology, National Defense Medical College, Saitama, Japan
    • Corresponding Author InformationCorrespondence and requests for reprints: Urological Oncology Research Laboratory, Department of Urology, Weill Medical College of Cornell University, 525 East 68th St., E-300, New York, New York 10021 (telephone: 212-746-5495; FAX: 212-746-8941)
    • ,
  • Makoto Sumitomo

      Affiliations

    • Department of Urology, National Defense Medical College, Saitama, Japan
    • ,
  • Junichi Asakuma

      Affiliations

    • Department of Urology, National Defense Medical College, Saitama, Japan
    • ,
  • Takako Asano

      Affiliations

    • Department of Urology, National Defense Medical College, Saitama, Japan
    • ,
  • Rong Zheng

      Affiliations

    • Urological Oncology Research Laboratory, Department of Urology, Division of Hematology and Medical Oncology, and Department of Medicine, Weill Medical College of Cornell University, New York, New York
    • ,
  • Tomohiko Asano

      Affiliations

    • Department of Urology, National Defense Medical College, Saitama, Japan
    • ,
  • David M. Nanus

      Affiliations

    • Urological Oncology Research Laboratory, Department of Urology, Division of Hematology and Medical Oncology, and Department of Medicine, Weill Medical College of Cornell University, New York, New York
    • Financial interest and/or other relationship with Amgen.
    • ,
  • Masamichi Hayakawa

      Affiliations

    • Department of Urology, National Defense Medical College, Saitama, Japan

Received 12 October 2005

References 

  1. Weigle DS , Bukowski TR , Foster DC , Holderman S , Kramer JM , Lasser G , et al.   Recombinant ob protein reduces feeding and body weight in the ob/ob mouse . J Clin Invest . 1995;96:2065
  2. Fantuzzi G , Faggioni R . Leptin in the regulation of immunity, inflammation, and hematopoiesis . J Leukoc Biol . 2000;68:437
  3. Frank S , Stallmeyer B , Kampfer H , Kolb N , Pfeilschifter J . Leptin enhances wound re-epithelialization and constitutes a direct function of leptin in skin repair . J Clin Invest . 2000;106:501
  4. Sierra-Honigmann MR , Nath AK , Murakami C , Garcia-Cardena G , Papapetropoulos A , Sessa WC , et al.   Biological action of leptin as an angiogenic factor . Science . 1998;281:1683
  5. Park HY , Kwon HM , Lim HJ , Hong BK , Lee JY , Park BE , et al.   Potential role of leptin in angiogenesis (leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro) . Exp Mol Med . 2001;33:95
  6. Ishikawa M , Kitayama J , Nagawa H . Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer . Clin Cancer Res . 2004;10:4325
  7. Rasmuson T , Grankvist K , Jacobsen J , Olsson T , Ljungberg B . Serum insulin-like growth factor-1 is an independent predictor of prognosis in patients with renal cell carcinoma . Acta Oncol . 2004;43:744
  8. Hu X , Juneja SC , Maihle NJ , Cleary MP . Leptin—a growth factor in normal and malignant breast cells and for normal mammary gland development . J Natl Cancer Inst . 2002;94:1704
  9. Frankenberry KA , Somasundar P , McFadden DW , Vona-Davis LC . Leptin induces cell migration and the expression of growth factors in human prostate cancer cells . Am J Surg . 2004;188:560
  10. Cauzac M , Czuba D , Girard J , Hauguel-de Mouzon S . Transduction of leptin growth signals in placental cells is independent of JAK-STAT activation . Placenta . 2003;24:378
  11. Yu MC , Ross RK . Obesity, hypertension, and renal cancer . N Engl J Med . 2001;344:531
  12. Goetze S , Bungenstock A , Czupalla C , Eilers F , Stawowy P , Kintscher U , et al.   Leptin induces endothelial cell migration through Akt, which is inhibited by PPARgamma-ligands . Hypertension . 2002;40:748
  13. Horiguchi A , Sumitomo M , Asakuma J , Asano T , Hayakawa M . 3-Hydroxy-3-methylglutaryl-coenzyme a reductase inhibitor, fluvastatin, as a novel agent for prophylaxis of renal cancer metastasis . Clin Cancer Res . 2004;10:8648
  14. Attoub S , Noe V , Pirola L , Bruyneel E , Chastre E , Mareel M , et al.   Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, rho-, and rac-dependent signaling pathways . FASEB J . 2000;14:2329
  15. Jo M , Thomas KS , Somlyo AV , Somlyo AP , Gonias SL . Cooperativity between the Ras-ERK and Rho-Rho kinase pathways in urokinase-type plasminogen activator-stimulated cell migration . J Biol Chem . 2002;277:12479
  16. Takahashi Y , Okimura Y , Mizuno I , Takahashi T , Kaji H , Uchiyama T , et al.   Leptin induces tyrosine phosphorylation of cellular proteins including STAT-1 in human renal adenocarcinoma cells, ACHN . Biochem Biophys Res Commun . 1996;228:859
  17. Oelmann E , Haghgu S , Kulimova E , Serve H , Schmitmann C , Berdel WE . Re (Leptin–a growth factor in normal and malignant breast cells and for normal mammary gland development) . J Natl Cancer Inst . 2003;95:1171
  18. Brahmbhatt AA , Klemke RL . ERK and RhoA differentially regulate pseudopodia growth and retraction during chemotaxis . J Biol Chem . 2003;278:13016
  19. Pawlak G , Helfman DM . Post-transcriptional down-regulation of ROCKI/Rho-kinase through an MEK-dependent pathway leads to cytoskeleton disruption in Ras-transformed fibroblasts . Mol Biol Cell . 2002;13:336
  20. Tourani JM , Pfister C , Tubiana N , Ouldkaci M , Prevot G , Lucas V , et al.  Subcutaneous Administration Propeukin Program Cooperative Group   Subcutaneous interleukin-2 and interferon alfa administration in patients with metastatic renal cell carcinoma (final results of SCAPP III, a large, multicenter, phase II, nonrandomized study with sequential analysis design) . J Clin Oncol . 2003;21:3987

PII: S0022-5347(06)01416-9

doi: 10.1016/j.juro.2006.06.040

The Journal of Urology
Volume 176, Issue 4 , Pages 1636-1641 , October 2006

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