The Journal of Urology
Volume 176, Issue 4 , Pages 1631-1635 , October 2006

Increased Serum Leptin Levels and Over Expression of Leptin Receptors are Associated With the Invasion and Progression of Renal Cell Carcinoma

  • Akio Horiguchi

      Affiliations

    • Department of Urology, National Defense Medical College, Tokorozawa-City, Saitama, Japan
    • Urological Oncology Research Laboratory, Department of Urology, Weill Medical College of Cornell University, New York, New York
    • Corresponding Author InformationCorrespondence and requests for reprints: Urological Oncology Research Laboratory, Department of Urology, Weill Medical College of Cornell University, 525 East 68th St., E-300, New York, New York 10021 (telephone: 1-212-746-5495; FAX: 1-212-746-8941)
    • ,
  • Makoto Sumitomo

      Affiliations

    • Department of Urology, National Defense Medical College, Tokorozawa-City, Saitama, Japan
    • ,
  • Junichi Asakuma

      Affiliations

    • Department of Urology, National Defense Medical College, Tokorozawa-City, Saitama, Japan
    • ,
  • Takako Asano

      Affiliations

    • Department of Urology, National Defense Medical College, Tokorozawa-City, Saitama, Japan
    • ,
  • Rong Zheng

      Affiliations

    • Urological Oncology Research Laboratory, Department of Urology, Weill Medical College of Cornell University, New York, New York
    • ,
  • Tomohiko Asano

      Affiliations

    • Department of Urology, National Defense Medical College, Tokorozawa-City, Saitama, Japan
    • ,
  • David M. Nanus

      Affiliations

    • Urological Oncology Research Laboratory, Department of Urology, Weill Medical College of Cornell University, New York, New York
    • Financial interest and/or other relationship with Amgen.
    • ,
  • Masamichi Hayakawa

      Affiliations

    • Department of Urology, National Defense Medical College, Tokorozawa-City, Saitama, Japan

Received 10 October 2005

References 

  1. Weigle DS , Bukowski TR , Foster DC , Holderman S , Kramer JM , Lasser G , et al.   Recombinant ob protein reduces feeding and body weight in the ob/ob mouse . J Clin Invest . 1995;96:2065
  2. Fantuzzi G , Faggioni R . Leptin in the regulation of immunity, inflammation, and hematopoiesis . J Leukoc Biol . 2000;68:437
  3. Sierra-Honigmann MR , Nath AK , Murakami C , Garcia-Cardena G , Papapetropoulos A , Sessa WC , et al.   Biological action of leptin as an angiogenic factor . Science . 1998;281:1683
  4. Goetze S , Bungenstock A , Czupalla C , Eilers F , Stawowy P , Kintscher U , et al.   Leptin induces endothelial cell migration through Akt, which is inhibited by PPARgamma-ligands . Hypertension . 2002;40:748
  5. Hu X , Juneja SC , Maihle NJ , Cleary MP . Leptin—a growth factor in normal and malignant breast cells and for normal mammary gland development . J Natl Cancer Inst . 2002;94:1704
  6. Laud K , Gourdou I , Pessemesse L , Peyrat JP , Djiane J . Identification of leptin receptors in human breast cancer (functional activity in the T47-D breast cancer cell line) . Mol Cell Endocrinol . 2002;188:219
  7. Dieudonne MN , Machinal-Quelin F , Serazin-Leroy V , Leneveu MC , Pecquery R , Giudicelli Y . Leptin mediates a proliferative response in human MCF7 breast cancer cells . Biochem Biophys Res Commun . 2002;293:622
  8. Stattin P , Soderberg S , Hallmans G , Bylund A , Kaaks R , Stenman UH , et al.   Leptin is associated with increased prostate cancer risk (a nested case-referent study) . J Clin Endocrinol Metab . 2001;86:1341
  9. Tessitore L , Vizio B , Pesola D , Cecchini F , Mussa A , Argiles JM , et al.   Adipocyte expression and circulating levels of leptin increase in both gynaecological and breast cancer patients . Int J Oncol . 2004;24:1529
  10. Stattin P , Lukanova A , Biessy C , Soderberg S , Palmqvist R , Kaaks R , et al.   Obesity and colon cancer (does leptin provide a link?) . Int J Cancer . 2004;109:149
  11. Ishikawa M , Kitayama J , Nagawa H . Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer . Clin Cancer Res . 2004;10:4325
  12. Tourani JM , Pfister C , Tubiana N , Ouldkaci M , Prevot G , Lucas V , et al.  Subcutaneous Administration Propeukin Program Cooperative Group   Subcutaneous interleukin-2 and interferon alfa administration in patients with metastatic renal cell carcinoma (final results of SCAPP III, a large, multicenter, phase II, nonrandomized study with sequential analysis design) . J Clin Oncol . 2003;21:3987
  13. Yu MC , Ross RK . Obesity, hypertension, and renal cancer . N Engl J Med . 2001;344:531
  14. Moyad MA . Obesity, interrelated mechanisms, and exposures and kidney cancer . Semin Urol Oncol . 2001;19:270
  15. Horiguchi A , Oya M , Shimada T , Uchida A , Marumo K , Murai M . Activation of signal transducer and activator of transcription 3 in renal cell carcinoma (a study of incidence and its association with pathological features and clinical outcome) . J Urol . 2002;168:762
  16. Saglam K , Aydur E , Yilmaz M , Goktas S . Leptin influences cellular differentiation and progression in prostate cancer . J Urol . 2003;169:1308
  17. Rasmuson T , Grankvist K , Jacobsen J , Olsson T , Ljungberg B . Serum insulin-like growth factor-1 is an independent predictor of prognosis in patients with renal cell carcinoma . Acta Oncol . 2004;43:744
  18. Oelmann E , Haghgu S , Kulimova E , Serve H , Schmitmann C , Berdel WE . Re (leptin—a growth factor in normal and malignant breast cells and for normal mammary gland development) . J Natl Cancer Inst . 2003;95:1171
  19. Attoub S , Noe V , Pirola L , Bruyneel E , Chastre E , Mareel M , et al.   Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, rho-, and rac-dependent signaling pathways . Faseb J . 2000;14:2329
  20. Hotakainen K , Ljungberg B , Haglund C , Nordling S , Paju A , Stenman UH . Expression of the free beta-subunit of human chorionic gonadotropin in renal cell carcinoma (prognostic study on tissue and serum) . Int J Cancer . 2003;104:631

PII: S0022-5347(06)01415-7

doi: 10.1016/j.juro.2006.06.039

The Journal of Urology
Volume 176, Issue 4 , Pages 1631-1635 , October 2006

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