The Journal of Urology
Volume 176, Issue 4 , Pages 1415-1419 , October 2006

Long-Term Outcome of High Dose Intensity Modulated Radiation Therapy for Patients With Clinically Localized Prostate Cancer

  • Michael J. Zelefsky

      Affiliations

    • Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York
    • Nothing to disclose.
    • Corresponding Author InformationCorrespondence and requests for reprints: Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., New York, New York 10021 (telephone: 212-639-6802; FAX: 212-639-8876).
    • ,
  • Heather Chan

      Affiliations

    • Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York
    • Nothing to disclose.
    • ,
  • Margie Hunt

      Affiliations

    • Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York
    • Nothing to disclose.
    • ,
  • Yoshiya Yamada

      Affiliations

    • Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York
    • Financial interest and/or other relationship with Varian Medical.
    • ,
  • Alison M. Shippy

      Affiliations

    • Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York
    • Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York
    • Nothing to disclose.
    • ,
  • Howard Amols

      Affiliations

    • Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York
    • Nothing to disclose.

Received 10 November 2005

References 

  1. Pollack A , Zagars GK , Starkschall G , Antolak JA , Lee JJ , Huang E , et al.   Prostate cancer radiation dose response (results of the M. D. Anderson phase III randomized trial) . Int J Radiat Oncol Biol Phys . 2002;53:1097
  2. Zietman AL , DeSilvio ML , Slater JD , Rossi CJ , Miller DW , Adams JA , et al.   Comparison of conventional-dose vs high-dose conformal radiation therapy in clinically localized adenocarcinoma of the prostate . JAMA . 2005;294:1233
  3. Zelefsky MJ , Fuks Z , Hunt M , Lee HJ , Lombardi D , Ling CC , et al.   High dose radiation delivered by intensity modulated conformal radiotherapy improves the outcome of localized prostate cancer . J Urol . 2001;166:876
  4. Meerleer G , Vakaet L , Meersschout S , Villeirs G , Verbaeys A , Oosterlinck W , et al.   Intensity modulated radiotherapy as primary treatment for prostate cancer (acute toxicity in 114 patients) . Int J Radiat Oncol Biol Phys . 2004;60:777
  5. Symon Z , Griffith KA , McLaughlin W , Sullivan M , Sandler HM . Dose escalation for localized prostate cancer (substantial benefit observed with 3D conformal therapy) . Int J Radiat Oncol Biol Phys . 2003;57:384
  6. Bey P , Carrie C , Beckendorf V , Ginestet C , Aletti P , Madelis G , et al.   Dose escalation with 3D-CRT in prostate cancer (French study of dose escalation with conformal radiotherapy in prostate cancer–preliminary results) . Int J Radiat Oncol Biol Phys . 2000;48:513
  7. Pollack A , Hanlon AL , Horwitz EM , Feigenberg SJ , Uzzo RG , Hanks GE . Prostate cancer radiotherapy dose response (an update of the Fox Chase experience) . J Urol . 2004;171:1132
  8. Cheung R , Tucker SL , Dong L , Kuban D . Dose-response for biochemical control among high risk prostate cancer patients after external beam radiotherapy . Int J Radiat Oncol Biol Phys . 2003;56:1234
  9. Lyons JA , Kupelian PA , Mohan DS , Reddy CA , Klein EA . Importance of high radiation doses (72 Gy or greater) in the treatment of stage T1-T3 adenocarcinoma of the prostate . Urology . 2000;55:85
  10. Zelefsky MJ , Cowen D , Fuks Z , Shike M , Burman C , Jackson A , et al.   Long term tolerance of high dose three dimensional conformal radiotherapy in patients with localized prostate cancer . Cancer . 1999;85:2460
  11. Storey MR , Pollack A , Zagars G , Smith L , Antolak J , Rosen I . Complications from radiotherapy dose escalation in prostate cancer (preliminary results of a randomized trial) . Int J Radiat Oncol Biol Phys . 2000;48:635
  12. Jackson A , Skwarchuk MW , Zelefsky MJ , Cowen DM , Venkatraman ES , Levegrun S , et al.   Late rectal bleeding after conformal radiotherapy of prostate cancer. II. Volume effects and dose-volume histograms . Int J Radiat Oncol Biol Phys . 2001;49:685
  13. Zelefsky MJ , Fuks Z , Happersett L , Lee HJ , Ling CC , Burman CM , et al.   Clinical experience with intensity modulated radiation therapy (IMRT) in prostate cancer . Radioth Oncol . 2000;55:241
  14. Burman CM , Chui CS , Kutcher GJ , Leibel SA , Zelefsky MJ , LoSasso TJ , et al.   Planning, delivery, and quality assurance of intensity-modulated radiotherapy using dynamic multileaf collimator (a strategy for large-scale implementation for the treatment of carcinoma of the prostate) . Int J Radiat Oncol Biol Phys . 1997;39:863
  15. American Society for Therapeutic Radiology and Oncology Panel . Consensus statement (guidelines for PSA following radiation therapy) . Int J Radiat Oncol Biol Phys . 1997;37:1035
  16. Thames EM , Kuban DA , Levy LB , Horwitz EM , Kupelian PA , Martinez AA , et al.   Comparison of alternating biochemical failure definitions based on clinical outcome in 4839 prostate cancer patients treated by external radiation therapy between 1986 and 1995 . Int J Radiat Oncol Biol Phys . 2003;57:929
  17. Kry SF , Salehpour M , Followil DS , Stoval M , Kuban DA , White RA , et al.   The calculated risk of secondary fatal malignancies from intensity modulated radiation therapy . Int J Radiat Oncol Biol Phys . 2005;62:1195
  18. Della Biancia C , Hunt M , Amols H . A comparison of the integral dose from 3D conformal and IMRT techniques in the treatment of prostate cancer . Med Phys . 2002;29:1216

 Editor’s Note: This article is the third of 5 published in this issue for which category 1 CME credits can be earned. Instructions for obtaining credits are given with the questions on pages 1690 and 1691.

PII: S0022-5347(06)01371-1

doi: 10.1016/j.juro.2006.06.002

The Journal of Urology
Volume 176, Issue 4 , Pages 1415-1419 , October 2006

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