The Journal of Urology
Volume 176, Issue 1 , Pages 127-131 , July 2006

Renal Stone Risk in a Simulated Microgravity Environment: Impact of Treadmill Exercise With Lower Body Negative Pressure

  • Manoj Monga

      Affiliations

    • Department of Urologic Surgery, University of Minnesota, Minneapolis, Minnesota
    • Department of Orthopedic Surgery, University of California-San Diego, San Diego, California
    • Corresponding Author InformationCorrespondence: Department of Urologic Surgery, University of Minnesota, 1420 Delaware St. Southeast, MMC 394, Minneapolis, Minnesota 55455 (telephone: 612-625-3209; FAX: 612-725-2232).
    • Financial interest and/or other relationship with Bard, Cook, Microvasive, Applied, Storz, Wolf, ACMI, Stryker, Olympus, Boehringer, Merck and Pfizer.
    • ,
  • Brandon Macias

      Affiliations

    • Department of Urologic Surgery, University of Minnesota, Minneapolis, Minnesota
    • Department of Orthopedic Surgery, University of California-San Diego, San Diego, California
    • ,
  • Eli Groppo

      Affiliations

    • Department of Urologic Surgery, University of Minnesota, Minneapolis, Minnesota
    • Department of Orthopedic Surgery, University of California-San Diego, San Diego, California
    • ,
  • Monica Kostelec

      Affiliations

    • Department of Urologic Surgery, University of Minnesota, Minneapolis, Minnesota
    • Department of Orthopedic Surgery, University of California-San Diego, San Diego, California
    • ,
  • Alan Hargens

      Affiliations

    • Department of Urologic Surgery, University of Minnesota, Minneapolis, Minnesota
    • Department of Orthopedic Surgery, University of California-San Diego, San Diego, California

Received 1 August 2005

References 

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  12. Watanabe Y , Oshima H , Mizuno K , Sekiguch C , Fukunaga M , Kohri K , et al.   Intravenous pamidronate prevents femoral bone loss and renal stone formation during 90-day bed-rest . J Bone Mineral Res . 2004;19:1771
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  14. Morey-Holton ER , Whalen RT , Arnaud SB , Van der Meulen MC . The skeleton and its adaptation to gravity . In:  Fregly MJ ,  Blatteis CM editor. Handbook of Physiology: Section 4, Environmental Physiology. III: The Gravitational Environment. Microgravity . vol. 1: New York: Oxford University Press; 1996;p. 691–719 chapt. 31
  15. Watenpaugh DE , Fortney SM , Ballard RE , Lee SMC , Bennett BS , Murthy G , et al.   Lower body negative pressure exercise during bed rest maintains orthostatic tolerance . FASEB J . 1994;8:A261
  16. Cao P , Kimura S , Macias BR , Ueno T , Watenpaugh DE , Hargens AR . Exercise within lower body negative pressure partially counteracts lumbar spine deconditioning associated with 28 days bed rest . J Appl Physiol . 2005;99:39
  17. Smith SM , Davis-Street JE , Fesperman JV , Calkins DS , Bawa M , Macias BR , et al.   Evaluation of treadmill exercise in a lower body negative pressure chamber as a countermeasure for weightlessness-induced bone loss (a bed rest study with identical twins) . J Bone Mineral Res . 2003;18:2223
  18. Whitson PA , Pietrzyk RA , Pak CY , Cintron NM . Alterations in renal stone risk factors after space flight . J Urol . 1993;150:803
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 Study received approval from the Johnson Space Center and University of California, San Diego Institutional Review Boards.Supported by National Aeronautical and Space Administration 199-26-12-34 and National Institutes of Health MO1 RR00827.

PII: S0022-5347(06)00572-6

doi: 10.1016/S0022-5347(06)00572-6

The Journal of Urology
Volume 176, Issue 1 , Pages 127-131 , July 2006

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