The Journal of Urology
Volume 166, Issue 6 , Pages 2232-2236 , December 2001

INTRAVESICAL OXYBUTYNIN: MODE OF ACTION ASSESSED BY PASSIVE DIFFUSION AND ELECTROMOTIVE ADMINISTRATION WITH PHARMACOKINETICS OF OXYBUTYNIN AND N-DESETHYL OXYBUTYNIN

,Accepted 1 June 2001.

REFERENCES 

  1. Di Stasi SM , Giannantoni A , Vespasiani G , et al.   Intravesical electromotive administration of oxybutynin in patients with detrusor hyperreflexia unresponsive to standard anticholinergic regimens . J Urol . 2001;165:491
  2. Hughes KM , Lang JC , Lazare R , et al.   Measurement of oxybutynin and its N-desethyl metabolite in plasma, and its application to pharmacokinetic studies in young, elderly and frail elderly volunteers . Xenobiotica . 1992;22:859
  3. Madersbacher H , Knoll M . Intravesical application of oxybutynin: mode of action in controlling detrusor hyperreflexia. Preliminary results . Eur Urol . 1995;28:340
  4. Buyse G , Waldeck K , Verpoorten C , et al.   Intravesical oxybutynin for neurogenic bladder dysfunction: less systemic side effects due to reduced first pass metabolism . J Urol . 1998;160:892
  5. Di Stasi SM , Giannantoni A , Massoud R , et al.   Electromotive administration of oxybutynin into the human bladder wall . J Urol . 1997;158:228
  6. Waldeck K , Larsson B , Andersson KE . Comparison of oxybutynin and its active metabolite, N-desethyl-oxybutynin, in the human detrusor and parotid gland . J Urol . 1997;157:1093
  7. de Groat WC , Kawatani M , Hisamitsu T , et al.   Mechanisms underlying the recovery of urinary bladder function following spinal cord injury . J Auton Nerv Syst, suppl. . 1990;30:S71
  8. Palmer LS , Zebold K , Firlit CF , et al.   Complications of intravesical oxybutynin chloride therapy in the pediatric myelomeningocele population . J Urol . 1997;157:638

PII: S0022-5347(05)65540-1

The Journal of Urology
Volume 166, Issue 6 , Pages 2232-2236 , December 2001

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