The Journal of Urology
Volume 171, Issue 2, Supplement , Pages S25-S29, February 2004

Molecular Epidemiology of Androgen-Metabolic Loci in Prostate Cancer: Predisposition and Progression

  • NICK M. MAKRIDAKIS
    • ,
  • JUERGEN K.V. REICHARDT

      Affiliations

    • Corresponding Author InformationCorrespondence: Department of Biochemistry and Molecular Biology, Institute for Genetic Medicine, USC Keck School of Medicine, 2250 Alcazar St., Los Angeles, California 90089-9075 (telephone: 323-442-1529; FAX: 323-442-2764.
    • Supported by grants from the NCI (CA68581 and CA83112), Department of Defense (PC992018) and California Cancer Research Program (99-0053V-10150).

From the Department of Biochemistry and Molecular Biology, Institute for Genetic Medicine, USC Keck School of Medicine, Los Angeles, California

ABSTRACT 

Purpose

We review recent molecular epidemiological data with regard to the association between several allelic variants of certain androgen-metabolic genes and the predisposition to and progression of prostate cancer.

Materials and Methods

We review recent data dealing with genetic variations in androgens and the etiology of prostate cancer.

Results

Recent molecular epidemiological data support an association between several allelic variants of certain androgen-metabolic genes and the predisposition to and progression of prostate cancer. While some of the allelic variants examined are consistently shown to be associated with increased prostate cancer risk, most of the variants show significant variability in risk.

Conclusions

A multidisciplinary attack on this problem, involving biochemistry, molecular genetics, pharmacogenetics, endocrinology and epidemiology, may be a useful paradigm in the analysis of prostate cancer and other complex human diseases. Based on the reviewed literature, we propose a guide on how and which single nucleotide polymorphisms to use in linkage and association studies of multifactorial phenotypes.

Key Words:  epidemiology , molecular , metabolism , androgens , phenotype , pharmacogenetics

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 Submitted for publication September 29, 2004.For other articles on a related topic see pages 322 and 328.

PII: S0022-5347(05)62514-1

doi:10.1097/01.ju.0000107844.78769.35

Refers to erratum:

  • RE: MOLECULAR EPIDEMIOLOGY OF ANDROGENMETABOLIC LOCI IN PROSTATE CANCER: PREDISPOSITION AND PROGRESSION

    N.M. Makridakis, J.K.V. Reichardt
    The Journal of Urology December 2004 (Vol. 172, Issue 6, Part 1, Page 2483)

The Journal of Urology
Volume 171, Issue 2, Supplement , Pages S25-S29, February 2004

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