The Journal of Urology
Volume 172, Issue 6, Part 1 , Pages 2434-2439 , December 2004

CYCLOPHOSPHAMIDE INDUCED CYSTITIS ALTERS NEUROTROPHIN AND RECEPTOR TYROSINE KINASE EXPRESSION IN PELVIC GANGLIA AND BLADDER

REFERENCES 

  1. MacInnis BL , Campenot RB . Retrograde support of neuronal survival without retrograde transport of nerve growth factor . Science . 2002;295:1536
  2. Miller FD , Kaplan DR . On Trk for retrograde signaling . Neuron . 2001;32:767
  3. Kaplan DR , Miller FD . Signal transduction by the neurotrophin receptors . Curr Opin Cell Biol . 1997;9:213
  4. Lowe EM , Anand P , Terenghi G , Williams-Chestnut RE , Sinicropi DV , Osborne JL . Increased nerve growth factor levels in the urinary bladder of women with idiopathic sensory urgency and interstitial cystitis . BJU . 1997;79:572
  5. Okragly AJ , Niles AL , Saban R , Schmidt D , Hoffman RL , Warner TF , et al.   Elevated tryptase, nerve growth factor, neurotrophin-3 and glial cell line-derived neurotrophic factor levels in the urine of interstitial cystitis and bladder cancer patients . J Urol . 1999;161:438
  6. Qiao L , Vizzard MA . Cystitis-induced upregulation of tyrosine kinase (TrkA, TrkB) receptor expression and phosphorylation in rat micturition pathways . J Comp Neurol . 2002;454:200
  7. Steers WD , Kolbeck S , Creedon D , Tuttle JB . Nerve growth factor in the urinary bladder of the adult regulates neuronal form and function . J Clin Invest . 1991;88:1709
  8. Vizzard MA . Changes in urinary bladder neurotrophic factor mRNA and NGF protein following urinary bladder dysfunction . Exp Neurol . 2000;161:273
  9. Vaidyanathan S , Krishnan KR , Mansour P , Soni BM , McDicken I . p75 nerve growth factor receptor in the vesical urothelium of patients with neuropathic bladder: an immunohistochemical study . Spinal Cord . 1998;36:541
  10. Vizzard MA . Up-regulation of pituitary adenylate cyclase-activating polypeptide in urinary bladder pathways after chronic cystitis . J Comp Neurol . 2000;420:335
  11. Yoshimura N , De Groat WC . Increased excitability of afferent neurons innervating rat urinary bladder following chronic bladder inflammation . J Neurosci . 1999;19:4644
  12. Keast JR , Booth AM , De Groat WC . Distribution of neurons in the major pelvic ganglion of the rat which supply the bladder, colon or penis . Cell Tiss Res . 1989;256:105
  13. Zvarova K , Murray E , Vizzard MA . Changes in galanin immunoreactivity in rat lumbosacral spinal cord and dorsal root ganglia after spinal cord injury . J Comp Neurol . 2004;475:590
  14. Hu VY , Malley S , Dattilio A , Folsom JB , Zvara P , Vizzard MA . COX-2 and prostanoid expression in micturition pathways after cyclophosphamide-induced cystitis in the rat . Am J Physiol Regul Integr Comp Physiol . 2003;284:R574
  15. Low KG , Allen RG , Melner MH . Association of proenkephalin transcripts with polyribosomes in the heart . Mol Endocrinol . 1990;4:1408
  16. Dupont MC , Spitsbergen JM , Kim KB , Tuttle JB , Steers WD . Histological and neurotrophic changes triggered by varying models of bladder inflammation . J Urol . 2001;166:1111
  17. Bjorling DE , Jacobsen HE , Blum JR , Shih A , Beckman M , Wang ZY , et al.   Intravesical Escherichia coli lipopolysaccharide stimulates an increase in bladder nerve growth factor . BJU Int . 2001;87:697
  18. Ji RR , Woolf CJ . Neuronal plasticity and signal transduction in nociceptive neurons: implications for the initiation and maintenance of pathological pain . Neurobiol Dis . 2001;8:1
  19. Keast JR , Kepper ME . Differential regulation of trkA and p75 in noradrenergic pelvic autonomic ganglion cells after deafferentation of their cholinergic neighbours . Eur J Neurosci . 2001;13:211
  20. Birder LA , Kanai AJ , de Groat WC , Kiss S , Nealen ML , Burke NE , et al.   Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells . Proc Natl Acad Sci USA . 2001;98:13396

 Accepted for publication June 4, 2004.Supported by National Institutes of Health Grants DK051369, DK060481, NS040769 and DK065989.

PII: S0022-5347(05)61432-2

doi: 10.1097/01.ju.0000143549.29867.4e

The Journal of Urology
Volume 172, Issue 6, Part 1 , Pages 2434-2439 , December 2004

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