The Journal of Urology
Volume 172, Issue 4, Supplement , Pages 1595-1599 , October 2004

UNILATERAL URETERAL OBSTRUCTION INDUCES RENAL TUBULAR CELL PRODUCTION OF TUMOR NECROSIS FACTOR-α INDEPENDENT OF INFLAMMATORY CELL INFILTRATION

REFERENCES 

  1. Donnahoo KK , Meng X , Ayala A , Cain MP , Harken AH , Meldrum DR . Early kidney TNF-alpha expression mediates neutrophil infiltration and injury after renal ischemia-reperfusion . Am J Physiol . 1999;277:R922
  2. Schreiner GF , Harris KP , Purkerson ML , Klahr S . Immunological aspects of acute ureteral obstruction: immune cell infiltrate in the kidney . Kidney Int . 1988;34:487
  3. Nagle RB , Bulger RE , Cutler RE , Jervis HR , Benditt EP . Unilateral obstructive nephropathy in the rabbit. I. Early morphologic, physiologic, and histochemical changes . Lab Invest . 1973;28:456
  4. Sharma AK , Mauer SM , Kim Y , Michael AF . Interstitial fibrosis in obstructive nephropathy . Kidney Int . 1993;44:774
  5. Truong LD , Sheikh-Hamad D , Chakraborty S , Suki WN . Cell apoptosis and proliferation in obstructive uropathy . Semin Nephrol . 1998;18:641
  6. Meldrum KK , Meldrum DR , Hile KL , Yerkes EB , Ayala A , Cain MP , et al.   p38 MAPK mediates renal tubular cell TNF-alpha production and TNF-alpha-dependent apoptosis during simulated ischemia . Am J Physiol Cell Physiol . 2001;281:C563
  7. Soler PA , Mullin JM , Knudsen KA , Marano CW . Tissue remodeling during tumor necrosis factor-induced apoptosis in LLC-PK1 renal epithelial cells . Am J Physiol . 1996;270:F869
  8. Meldrum KK , Meldrum DR , Meng X , Ao L , Harken AH . TNF-alpha-dependent bilateral renal injury is induced by unilateral renal ischemia-reperfusion . Am J Physiol Heart Circ Physiol . 2002;282:H540
  9. Guo G , Morrissey J , McCracken R , Tolley T , Liapis H , Klahr S . Contributions of angiotensin II and tumor necrosis factor-alpha to the development of renal fibrosis . Am J Physiol Renal Physiol . 2001;280:F777
  10. Donnahoo KK , Meng X , Ao L , Ayala A , Shames BD , Cain MP , et al.   Differential cellular immunolocalization of renal tumour necrosis factor-alpha production during ischaemia versus endotoxaemia . Immunology . 2001;102:53
  11. Kaneto H , Morrissey J , McCracken R , Ishidoya S , Reyes A , Klahr S . The expression of mRNA for tumor necrosis factor-alpha increases in the obstructed kidney of rats soon after unilateral ureteral ligation . Nephrology . 1996;2:161
  12. Klahr S , Morrissey J . Obstructive nephropathy and renal fibrosis . Am J Physiol Renal Physiol . 2002;283:F861
  13. Klahr S , Morrissey JJ . The role of growth factors, cytokines, and vasoactive compounds in obstructive nephropathy . Semin Nephrol . 1998;18:622
  14. Moody TE , Vaughan ED , Gillenwater JY . Comparison of the renal hemodynamic response to unilateral and bilateral ureteral occlusion . Invest Urol . 1977;14:455
  15. Gobe G , Willgoss D , Hogg N , Schoch E , Endre Z . Cell survival or death in renal tubular epithelium after ischemia-reperfusion injury . Kidney Int . 1999;56:1299
  16. Diamond JR , Ricardo SD , Klahr S . Mechanisms of interstitial fibrosis in obstructive nephropathy . Semin Nephrol . 1998;18:594
  17. Yang J , Liu Y . Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis . Am J Pathol . 2001;159:1465
  18. Strutz F , Muller GA . Transdifferentiation comes of age . Nephrol Dial Transplant . 2000;15:1729
  19. Iwano M , Plieth D , Danoff TM , Xue C , Okada H , Neilson EG . Evidence that fibroblasts derive from epithelium during tissue fibrosis . J Clin Invest . 2002;110:341
  20. Zeisberg M , Bonner G , Maeshima Y , Colorado P , Muller GA , Strutz F , et al.   Renal fibrosis: collagen composition and assembly regulates epithelial-mesenchymal transdifferentiation . Am J Pathol . 2001;159:1313

 Supported by the Clarian Values Fund for Research and the Indiana University Department of Urology.Papers Presented at Annual Meeting of the Section on Urology, American Academy of Pediatrics

PII: S0022-5347(05)61316-X

doi: 10.1097/01.ju.0000138902.57626.70

The Journal of Urology
Volume 172, Issue 4, Supplement , Pages 1595-1599 , October 2004