The Journal of Urology
Volume 172, Issue 5, Part 1 , Pages 2069-2072 , November 2004

BLOCK OF EXTERNAL URETHRAL SPHINCTER CONTRACTION BY HIGH FREQUENCY ELECTRICAL STIMULATION OF PUDENDAL NERVE

  • CHANGFENG TAI

      Affiliations

    • Corresponding Author InformationCorrespondence: Department of Pharmacology, University of Pittsburgh, W1354 Biomedical Science Tower, Pittsburgh, Pennsylvania 15261 (telephone: 412-648-7016; FAX: 412-648-1945)
  • ,
  • JAMES R. ROPPOLO
  • ,
  • WILLIAM C. de GROAT

      Affiliations

    • Financial interest and/or other relationship with Abbott, Roche Palo Alto, Eli Lilly, Pfizer, Novartis, Dynogen, Johnson and Johnson, Urogene, Newron, ICOS and Neurogen

REFERENCES 

  1. de Groat WC , Booth AM , Yoshimura N . Neurophysiology of micturition and its modification in animal models of human disease . In:  Maggi CA editors. The Autonomic Nervous System, Nervous Control of the Urogenital System . vol. 3: London: Harwood Academic Publishers; 1993;p. 227–289 chapt. 8
  2. Shefchyk SJ . Spinal cord neural organization controlling the urinary bladder and striated sphincter . Prog Brain Res . 2002;137:71
  3. Burns AS , Rivas DA , Ditunno JF . The management of neurogenic bladder and sexual dysfunction after spinal cord injury . Spine . 2001;26(suppl):s129
  4. Catz A , Luttwak ZP , Agranov E , Ronen J , Shpaser R , Paz A , et al.   The role of external sphincterotomy for patients with spinal cord lesion . Spinal Cord . 1997;35:48
  5. Yoshimura N , Smith CP , Chancellor MB , De Groat WC . Pharmacologic and potential biologic interventions to restore bladder function after spinal cord injury . Curr Opin Neurol . 2000;13:677
  6. Chancellor MB , Rivas DA , Abdill CK , Karasick S , Ehrlich SM , Staas WE . Prospective comparison of external sphincter balloon dilatation and prosthesis placement with external sphincterotomy in spinal cord injured men . Arch Phys Med Rehab . 1994;75:297
  7. Chancellor MB , Gajewski J , Ackman CFD , Appell RA , Bennett J , Binard J , et al.   Long-term followup of the North American multicenter UroLume trial for the treatment of external detrusor-sphincter dyssynergia . J Urol . 1999;161:1545
  8. Vapnek JM , Couillard DR , Stone AR . Is sphincterotomy the best management of the spinal cord injured bladder? . J Urol . 1994;151:961
  9. Tsai SJ , Lew HL , Date E , Bih LI . Treatment of detrusor-sphincter dyssynergia by pudendal nerve block in patient with spinal cord injury . Arch Phys Med Rehabil . 2002;83:714
  10. Ishigooka M , Hashimoto T , Sasagawa I , Izumiya K , Nakada T . Modulation of the urethral pressure by high-frequency block stimulation in dogs . Eur Urol . 1994;25:334
  11. Sweeney JD , Mortimer JT , Bodner DR . Acute animal studies of electrically induced collision block of pudendal nerve motor activity . Neurourol Urodyn . 1989;8:521
  12. Lindström  , Fall M , Carlsson C-A , Erlandson B-E . The neurophysiological basis of bladder inhibition in response to intravaginal electrical stimulation . J Urol . 1983;129:405
  13. Schmidt RA . Neural prostheses and bladder control . Eng Med Bio Magazine . 1983;2:31
  14. Haleem AS , Boehm F , Legatt AD , Kantrowitz A , Stone B , Melman A . Sacral root stimulation for controlled micturition: prevention of detrusor-external sphincter dyssynergia by intraoperative identification and selective section of sacral nerve branches . J Urol . 1993;149:1607
  15. van Kerrebroeck PEV , Koldewijn EL , Rosier PFWM , Wijkstra H , Debruyne FMJ . Results of the treatment of neurogenic bladder dysfunction in spinal cord injury by sacral posterior root rhizotomy and anterior sacral root stimulation . J Urol . 1996;155:1378
  16. Bowman BR , McNeal DR . Response of single alpha motoneurons to high-frequency pulse trains . Firing behavior and conduction block phenomenon. Appl Neurophysiol . 1986;49:121
  17. Agnew WF , McCreery DB . Neural Prostheses: Fundamental Studies . Englewood Cliffs, New Jersey: Prentice Hall; 1990;
  18. Xu J , Shepherd RK , Millard RE , Clark GM . Chronic electrical stimulation of the auditory nerve at high stimulus rates: a physiological and histopathological study . Hearing Res . 1997;105:1
  19. Rubinstein JT , Tyler RS , Johnson A , Brown CJ . Electrical suppression of tinnitus with high-rate pulse trains . Otol Neurotol . 2003;24:478
  20. Ratty F . High frequency electrostimulation of excitable cells . J Theor Biol . 1986;123:45

 Accepted for publication June 11, 2004.Study received animal care and use committee approval.Supported by National Institutes of Health Grants 1R01-DK-068566-01 and 1R01-NS-045078-01.

PII: S0022-5347(05)60930-5

doi: 10.1097/01.ju.0000140709.71932.f0

The Journal of Urology
Volume 172, Issue 5, Part 1 , Pages 2069-2072 , November 2004