The Journal of Urology
Volume 174, Issue 1 , Pages 161-164 , July 2005

TREATMENT OF CHRONIC BACTERIAL PROSTATITIS WITH LEVOFLOXACIN AND CIPROFLOXACIN LOWERS SERUM PROSTATE SPECIFIC ANTIGEN

  • ANTHONY J. SCHAEFFER

      Affiliations

    • Financial interest and/or other relationship with Ortho-McNeil, Proctor & Gamble, Urologix and Boehringer Ingelheim.
    • ,
  • SHU-CHEN WU

      Affiliations

    • Financial interest and/or other relationship with Ortho-McNeil Pharmaceutical.
    • ,
  • ALAN M. TENNENBERG

      Affiliations

    • Financial interest and/or other relationship with Johnson and Johnson.
    • ,
  • JAMES B. KAHN

      Affiliations

    • Corresponding Author InformationOrtho-McNeil Pharmaceutical, Inc. 1000 Route 202, Room 3162, Raritan, New Jersey 08869-0602 (telephone: 908-704-5262; FAX: 908-218-1286).

References 

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  2. Schaeffer AJ , Landis JR , Knauss JS , Propert KJ , Alexander RB , Litwin MS , et al.   Demographic and clinical characteristics of men with chronic prostatitis: the National Institutes of Health Chronic Prostatitis Cohort study . J Urol . 2002;168:593
  3. Nickel JC , Downey J , Clark J , Casey RW , Pommerville PJ , Barkin J , et al.   Levofloxacin for chronic prostatitis/chronic pelvic pain syndrome in men: a randomized placebo-controlled multicenter trial . Urology . 2003;62:614
  4. Nickel JC , Alexander RB , Schaeffer AJ , Landis JR , Knauss JS , Propert KJ , et al.   Leukocytes and bacteria in men with chronic prostatitis/chronic pelvic pain syndrome compared to asymptomatic controls . J Urol . 2003;170:818
  5. Potts JM . Prospective identification of National Institutes of Health category IV prostatitis in men with elevated prostate specific antigen . J Urol . 2000;164:1550
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  7. Carver BS , Bozeman CB , Williams BJ , Venable DD . The prevalence of men with National Institutes of Health category IV prostatitis and association with serum prostate specific antigen . J Urol . 2003;169:589
  8. Catalona WJ , Smith DS , Ratliff TL , Basler JW . Detection of organ-confined prostate cancer is increased through prostate-specific antigen-based screening . JAMA . 1993;270:948
  9. Bozeman CB , Carver BS , Eastham JA , Venable DD . Treatment of chronic prostatitis lowers serum prostate specific antigen . J Urol . 2002;167:1723
  10. Karazanashvili G , Managadze L . Prostate-specific antigen (PSA) value change after antibacterial therapy of prostate inflammation, as a diagnostic method for prostate cancer screening in cases of PSA value within 4–10 ng/ml and nonsuspicious results of digital rectal examination . Eur Urol . 2001;39:538
  11. Bundrick W , Heron SP , Ray P , Schiff WM , Tennenberg AM , Wiesinger BA , et al.   Levofloxacin versus ciprofloxacin in the treatment of chronic bacterial prostatitis: a randomized double-blind multicenter study . Urology . 2003;62:537
  12. Meares EMJ , Stamey TA . Bacterial prostatitis and recurrent urinary tract infections . In:  Hoeprich PD editors. Infectious Diseases . Hagerstown, Maryland: Harper and Row; 1972;p. 467–473
  13. Bulbul MA , Wazzan W , Hijaz A , Shaar A . The effect of antibiotics on elevated serum prostate specific antigen in patients with urinary symptoms and negative digital rectal examination: a pilot study . J Med Liban . 2002;50:23
  14. Tchetgen MB , Oesterling JE . The effect of prostatitis, urinary retention, ejaculation, and ambulation on the serum prostate-specific antigen concentration . Urol Clin North Am . 1997;24:283
  15. Eskew LA , Bare RL , McCullough DL . Systemic 5 region prostate biopsy is superior to sextant method for diagnosing carcinoma of the prostate . J Urol . 1997;157:199
  16. Keetch DW , Catalona WJ , Smith DS . Serial prostatic biopsies in men with persistently elevated serum prostate specific antigen values . J Urol . 1994;151:1571

 Submitted for publication August 12, 2004.

PII: S0022-5347(05)60049-3

doi: 10.1097/01.ju.0000162017.24965.2b

The Journal of Urology
Volume 174, Issue 1 , Pages 161-164 , July 2005

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