The Journal of Urology
Volume 174, Issue 1 , Pages 14-20 , July 2005

UPDATE ON CHEMOTHERAPY FOR ADVANCED BLADDER CANCER

  • JONATHAN E. ROSENBERG

      Affiliations

    • Corresponding Author InformationDivision of Hematology/Oncology, Department of Medicine, University of California-San Francisco, 1600 Divisadero St., Box 1711, San Francisco, California 94115 (telephone: 415-353-7095; FAX: 415-353-7779).
    • Financial interest and/or other relationship with Praecis Pharmaceuticals.
  • ,
  • PETER R. CARROLL

      Affiliations

    • Financial interest and/or other relationship with TAP Pharmaceuticals, National Institutes of Health, AstraZeneca and Imatrimus.
  • ,
  • ERIC J. SMALL

References 

  1. Jemal A , Murray T , Samuels A , Ghafoor A , Ward E , Thun MJ . Cancer statistics, 2003 . CA Cancer J Clin . 2003;53:5
  2. Cookson MS , Herr HW , Zhang Z-F , Soloway S , Sogani PC , Fair WR . The treated natural history of high risk superficial bladder cancer: 15- year outcome . J Urol . 1997;158:62
  3. Herr HW , Faulkner JR , Grossman HB , Natale RB , deVere White R , Sarosdy MF , et al.   Surgical factors influence bladder cancer outcomes: a cooperative group report . J Clin Oncol . 2004;22:2781
  4. Sanderson KM , Stein JP , Skinner DG . The evolving role of pelvic lymphadenectomy in the treatment of bladder cancer . Urol Oncol . 2004;22:205
  5. Stein JP , Lieskovsky G , Cote R , Groshen S , Feng AC , Boyd S , et al.   Radical cystectomy in the treatment of invasive bladder cancer: long-term results in 1,054 patients . J Clin Oncol . 2001;19:666
  6. Frank I , Cheville JC , Blute ML , Lohse CM , Nehra A , Weaver AL , et al.   Transitional cell carcinoma of the urinary bladder with regional lymph node involvement treated by cystectomy: clinicopathologic features associated with outcome . Cancer . 2003;97:2425
  7. Sternberg CN . Neo-adjuvant and adjuvant chemotherapy of bladder cancer: is there a role? . Ann Oncol . 2002;13(suppl.):273
  8. Millikan R , Dinney C , Swanson D , Sweeney P , Ro JY , Smith TL , et al.   Integrated therapy for locally advanced bladder cancer: final report of a randomized trial of cystectomy plus adjuvant M-VAC versus cystectomy with both preoperative and postoperative M-VAC . J Clin Oncol . 2001;19:4005
  9. Wallace DM , Raghavan D , Kelly KA , Sandeman TF , Conn IG , Teriana N , et al.   Neo-adjuvant (pre-emptive) cisplatin therapy in invasive transitional cell carcinoma of the bladder . Br J Urol . 1991;67:608
  10. Martinez-Piñeiro JA , Martin MG , Arocena F , Flores N , Roncero CR , Portillo JA , et al.   Neoadjuvant cisplatin chemotherapy before radical cystectomy in invasive transitional cell carcinoma of the bladder: a prospective randomized phase III study . J Urol . 1995;153:964
  11. Rintala E , Hannisdahl E , Fossa SD , Hellsten S , Sander S . Neoadjuvant chemotherapy in bladder cancer: a randomized study. Nordic Cystectomy Trial I . Scand J Urol Nephrol . 1993;27:355
  12. Malmstrom P-U , Rintala E , Wahlqvist R , Hellstrom P , Hellsten S , Hannisdal E . Five-year followup of a prospective trial of radical cystectomy and neoadjuvant chemotherapy: Nordic Cystectomy Trial I . J Urol . 1996;155:1903
  13. Neoadjuvant cisplatin, methotrexate, and vinblastine chemotherapy for muscle-invasive bladder cancer: a randomised controlled trial. International collaboration of trialists . Lancet . 1999;354:533
  14. Hall RR . Updated results of a randomized controlled trial of neoadjuvant cisplatin (C), methotrexate(M) and vinblastine (V) chemotherapy for muscle-invasive bladder cancer . Proc Am Soc Clin Oncol . 2002;21:178A; abstract 710
  15. Grossman HB , Natale RB , Tangen CM , Speights VO , Vogelzang NJ , Trump DL , et al.   Neoadjuvant chemotherapy plus cystectomy compared with cystectomy alone for locally advanced bladder cancer . N Engl J Med . 2003;349:859
  16. Advanced Bladder Cancer Meta-analysis Collaboration  . Neoadjuvant chemotherapy in invasive bladder cancer: a systematic review and meta-analysis . Lancet . 2003;361:1927
  17. Winquist E , Kirchner TS , Segal R , Chin J , Lukka H , on behalf of the Genirourinary Cancer Disease Site Group of Cancer Care Ontario Program in Evidence-Based Care Practice Guidelines Initiative  . Neoadjuvant chemotherapy for transitional cell carcinoma of the bladder: a systematic review and meta-analysis . J Urol . 2004;171:561
  18. Miladi M , Peyromaure M , Zerbib M , Saighi D , Debre B . The value of a second transurethral resection in evaluating patients with bladder tumours . Eur Urol . 2003;43:241
  19. Studer UE , Bacchi M , Biedermann C , Jaeger P , Kraft R , Mazzucchelli L , et al.   Adjuvant cisplatin chemotherapy following cystectomy for bladder cancer: results of a prospective randomized trial . J Urol . 1994;152:81
  20. Skinner DG , Daniels JR , Russell CA , Lieskovsky G , Boyd SD , Nichols P , et al.   The role of adjuvant chemotherapy following cystectomy for invasive bladder cancer: a prospective comparative trial . J Urol . 1991;145:459
  21. Freiha F , Reese J , Torti FM . A randomized trial of radical cystectomy versus radical cystectomy plus cisplatin, vinblastine and methotrexate chemotherapy for muscle invasive bladder cancer . J Urol . 1996;155:495
  22. Stöckle M , Meyenburg W , Wellek S , Voges G , Gertenbach U , Thüroff JW , et al.   Advanced bladder cancer (stages pT3b, pT4a, pN1 and pN2): improved survival after radical cystectomy and 3 adjuvant cycles of chemotherapy. Results of a controlled prospective study . J Urol . 1992;148:302
  23. Stockle M , Wellek S , Meyenburg W , Voges GE , Fischer U , Gertenbach U , et al.   Radical cystectomy with or without adjuvant polychemotherapy for non-organ-confined transitional cell carcinoma of the urinary bladder: prognostic impact of lymph node involvement . Urology . 1996;48:868
  24. Shipley WU , Kaufman DS , Zehr E , Heney NM , Lane SC , Thakral HK , et al.   Selective bladder preservation by combined modality protocol treatment: long-term outcomes of 190 patients with invasive bladder cancer . Urology . 2002;60:62
  25. Kim HL , Steinberg GD . The current status of bladder preservation in the treatment of muscle invasive bladder cancer . J Urol . 2000;164:627
  26. Shipley WU , Winter KA , Kaufman DS , Lee WR , Heney NM , Tester WR , et al.   Phase III trial of neoadjuvant chemotherapy in patients with invasive bladder cancer treated with selective bladder preservation by combined radiation therapy and chemotherapy: initial results of Radiation Therapy Oncology Group 89–03 . J Clin Oncol . 1998;16:3576
  27. Rodel C , Grabenbauer GG , Kuhn R , Papadopoulos T , Dunst J , Meyer M , et al.   Combined-modality treatment and selective organ preservation in invasive bladder cancer: long-term results . J Clin Oncol . 2002;20:3061
  28. Bajorin DF , Dodd PM , Mazumdar M , Fazzari M , McCaffrey JA , Scher HI , et al.   Long-term survival in metastatic transitional-cell carcinoma and prognostic factors predicting outcome of therapy . J Clin Oncol . 1999;17:3173
  29. Saxman SB , Propert KJ , Einhorn LH , Crawford ED , Tannock I , Raghavan D , et al.   Long-term follow-up of a phase III intergroup study of cisplatin alone or in combination with methotrexate, vinblastine, and doxorubicin in patients with metastatic urothelial carcinoma: a cooperative group study . J Clin Oncol . 1997;15:2564
  30. Logothetis CJ , Dexeus FH , Finn L , Sella A , Amato RJ , Ayala AG , et al.   A prospective randomized trial comparing MVAC and CISCA chemotherapy for patients with metastatic urothelial tumors . J Clin Oncol . 1990;8:1050
  31. von der Maase H , Hansen SW , Roberts JT , Dogliotti L , Oliver T , Moore MJ , et al.   Gemcitabine and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in advanced or metastatic bladder cancer: results of a large, randomized, multinational, multicenter, phase III study . J Clin Oncol . 2000;17:3068
  32. Sweeney P , Millikan R , Donat M , Wood CG , Radtke AS , Pettaway CA , et al.   Is there a therapeutic role for post-chemotherapy retroperitoneal lymph node dissection in metastatic transitional cell carcinoma of the bladder? . J Urol . 2003;169:2113
  33. Herr HW , Donat SM , Bajorin DF . Post-chemotherapy surgery in patients with unresectable or regionally metastatic bladder cancer . J Urol . 2001;165:811
  34. Paz-Ares L , Bezares S , Tabernero JM , Castellanos D , Cortes-Funes H . Review of a promising new agent—pemetrexed disodium . Cancer . 2003;97:2056
  35. Bellmunt J , Guillem V , Paz-Ares L , Gonzalez-Larriba JL , Carles J , Batiste-Alentorn E , et al.   Phase I-II study of paclitaxel, cisplatin, and gemcitabine in advanced transitional-cell carcinoma of the urothelium. Spanish Oncology Genitourinary Group . J Clin Oncol . 2000;18:3247
  36. Bajorin DF , McCaffrey JA , Dodd PM , Hilton S , Mazumdar M , Kelly WK , et al.   Ifosfamide, paclitaxel, and cisplatin for patients with advanced transitional cell carcinoma of the urothelial tract: final report of a phase II trial evaluating two dosing schedules . Cancer . 2000;88:1671
  37. Maluf F , Hilton S , Nanus D , Herr H , Mazumdar M , Higgins G , et al.   Sequential doxorubicin/gemcitabine and ifosfamide, paclitaxel, and cisplatin chemotherapy in patients with metastatic or locally advanced transitional cell carcinoma of the urothelium . Proc Am Soc Clin Oncol . 2000;18: abstract 1344
  38. Bellmunt J , Ribas A , Eres N , Albanell J , Almanza C , Bermejo B , et al.   Carboplatin-based versus cisplatin-based chemotherapy in the treatment of surgically incurable advanced bladder carcinoma . Cancer . 1997;80:1966
  39. Tu S-M , Hossan E , Amato R , Kilbourn R , Logothetis CJ . Paclitaxel, cisplatin and methotrexate combination chemotherapy is active in the treatment of refractory urothelial malignancies . J Urol . 1995;154:1719
  40. Witte RS , Elson P , Bono B , Knop R , Richardson RR , Dreicer R , et al.   Eastern Cooperative Oncology Group phase II trial of ifosfamide in the treatment of previously treated advanced urothelial carcinoma . J Clin Oncol . 1997;15:589
  41. McCaffrey JA , Hilton S , Mazumdar M , Sadan S , Kelly WK , Scher HI , et al.   Phase II trial of docetaxel in patients with advanced or metastatic transitional-cell carcinoma . J Clin Oncol . 1997;15:1853
  42. Sweeney CJ , Williams SD , Finch DE , Bihrle R , Foster RS , Collins M , et al.   A phase II study of paclitaxel and ifosfamide for patients with advanced refractory carcinoma of the urothelium . Cancer . 1999;86:514
  43. Roth BJ , Dreicer R , Einhorn LH , Neuberg D , Johnson DH , Smith JL , et al.   Significant activity of paclitaxel in advanced transitional-cell carcinoma of the urothelium: a phase II trial of the Eastern Cooperative Oncology Group . J Clin Oncol . 1994;12:2264
  44. Dreicer R , Gustin DM , See WA , Williams RD . Paclitaxel in advanced urothelial carcinoma: its role in patients with renal insufficiency and as salvage therapy . J Urol . 1996;156:1606
  45. Vaughn DJ , Broome CM , Hussain M , Gutheil JC , Markowitz AB . Phase II trial of weekly paclitaxel in patients with previously treated advanced urothelial cancer . J Clin Oncol . 2002;20:937
  46. Krege S , Rembrink V , Börgermann CH , Otto T , Rübben H . Docetaxel and ifosfamide as second line treatment for patients with advanced or metastatic urothelial cancer after failure of platinum chemotherapy: a phase 2 study . J Urol . 2001;165:67
  47. Neal DE , Sharples L , Smith K , Fennelly J , Hall RR , Harris AL . The epidermal growth factor receptor and the prognosis of bladder cancer . Cancer . 1990;65:1619
  48. Jimenez RE , Hussain M , Bianco FJ , Vaishampayan U , Tabazcka P , Sakr WA , et al.   Her-2/neu overexpression in muscle-invasive urothelial carcinoma of the bladder: prognostic significance and comparative analysis in primary and metastatic tumors . Clin Cancer Res . 2001;7:2440
  49. Sengelov L , von der Maase H , Lundbeck F , Barlebo H , Colstrup H , Engelholm SA , et al.   Neoadjuvant chemotherapy with cisplatin and methotrexate in patients with muscle-invasive bladder tumours . Acta Oncol . 2002;41:447

 Submitted for publication October 20, 2004.

PII: S0022-5347(05)60009-2

doi: 10.1097/01.ju.0000162039.38023.5f

The Journal of Urology
Volume 174, Issue 1 , Pages 14-20 , July 2005