The Journal of Urology
Volume 175, Issue 2 , Pages 500-504 , February 2006

Obesity, Serum Prostate Specific Antigen and Prostate Size: Implications for Prostate Cancer Detection

  • Stephen J. Freedland

      Affiliations

    • Department of Urology, Johns Hopkins School of Medicine, Baltimore, Maryland
    • Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland
    • Corresponding Author InformationCorrespondence and requests for reprints: Division of Urology, Duke University School of Medicine, Box 3850, DUMC, Durham, North Carolina 27710 (telephone: 919-668-8361FAX: 919-668-7117
    • ,
  • Elizabeth A. Platz

      Affiliations

    • Department of Urology, Johns Hopkins School of Medicine, Baltimore, Maryland
    • Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland
    • ,
  • Joseph C. Presti Jr

      Affiliations

    • Department of Urology, Stanford University School of Medicine and Department of Surgery, Veterans Administration Medical Center, Palo Alto
    • ,
  • William J. Aronson

      Affiliations

    • Department of Surgery, Veterans Administration Greater Los Angeles Healthcare System and Department of Urology, University of California-Los Angeles School of Medicine, Los Angeles
    • ,
  • Christopher L. Amling

      Affiliations

    • Department of Urology, San Diego Naval Hospital, San Diego
    • ,
  • Christopher J. Kane

      Affiliations

    • Department of Surgery, Veterans Administration Medical Center San Francisco and Department of Urology, University of California, School of Medicine, San Francisco, California
    • ,
  • Martha K. Terris

      Affiliations

    • Department of Surgery, Veterans Administration Medical Center and Section of Urology, Medical College of Georgia, Augusta, Georgia

Received 9 March 2005

References 

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  2. Bray GA . The underlying basis for obesity (relationship to cancer) . J Nutr . 2002;132(suppl):3451S
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  8. Dahle SE , Chokkalingam AP , Gao Y-T , Deng J , Stanczyk FZ , Hsing AW . Body size and serum levels of insulin and leptin in relation to the risk of benign prostatic hyperplasia . J Urol . 2002;168:599
  9. Hammarsten J , Hogstedt B . Hyperinsulinaemia as a risk factor for developing benign prostatic hyperplasia . Eur Urol . 2001;39:151
  10. Freedland SJ , Amling CL , Dorey F , Kane CJ , Presti JC , Terris MK , et al.   Race as an outcome predictor after radical prostatectomy (results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database) . Urology . 2002;60:670
  11. Lewis JS , Vollmer RT , Humphrey PA . Carcinoma extent in prostate needle biopsy tissue in the prediction of whole gland tumor volume in a screening population . Am J Clin Pathol . 2002;118:442
  12. Roberts RO , Jacobson DJ , Girman CJ , Rhodes T , Klee GG , Lieber MM , et al.   Insulin-like growth factor I, insulin-like growth factor binding protein 3, and urologic measures of benign prostatic hyperplasia . Am J Epidemiol . 2003;157:784
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  16. Gray MA , Delahunt B , Fowles JR , Weinstein P , Cookes RR , Nacey JN . Demographic and clinical factors as determinants of serum levels of prostate specific antigen and its derivatives . Anticancer Res . 2004;24:2069
  17. Ku JH , Kim ME , Lee NK , Park YH , Ahn JO . Influence of age, anthropometry, and hepatic and renal function on serum prostate-specific antigen levels in healthy middle-age men . Urology . 2003;61:132
  18. Kranse R , Beemsterboer P , Rietbergen J , Habbema D , Hugosson J , Schroder FH . Predictors for biopsy outcome in the European Randomized Study of Screening for Prostate Cancer (Rotterdam region) . Prostate . 1999;39:316
  19. Finne P , Finne R , Auvinen A , Juusela H , Aro J , Maattanen L , et al.   Predicting the outcome of prostate biopsy in screen-positive men by a multilayer perceptron network . Urology . 2000;56:418
  20. Freedland SJ , Terris MK , Platz EA , Presti JC . Body mass index as a predictor of prostate cancer (development versus detection on biopsy) . Urology . 2005;66:108
  21. Salomon L , Levrel O , Anastasiadis AG , Irani J , De La Taille A , Saint F , et al.   Prognostic significance of tumor volume after radical prostatectomy (a multivariate analysis of pathological prognostic factors) . Eur Urol . 2003;43:7739

 Study received Institutional Review Board approval at each institution.

 Supported by the Department of Veterans Affairs, National Institutes of Health R01CA100938 (WJA), National Institutes of Health Specialized Programs of Research Excellence Grant P50 CA92131-01A1 (WJA), National Institutes of Health Specialized Programs of Research Excellence Grant Career Development Award P50CA58236 (EAP), the Georgia Cancer Coalition (MKT), Center for Prostate Disease Research (CPDR), a grant from the United States Army Medical Research and Materiel Command (CLA), Department of Defense, Prostate Cancer Research Program PC030666 (SJF) and DAMD 17-03-1-0273 (EAP), and an American Foundation for Urologic Disease/American Urological Association Education and Research Scholarship Award (SJF).

 Views, opinions and endorsements are those of the authors.

PII: S0022-5347(05)00162-X

doi: 10.1016/S0022-5347(05)00162-X

The Journal of Urology
Volume 175, Issue 2 , Pages 500-504 , February 2006

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