The Journal of Urology
Volume 153, Issue 6 , Pages 1763-1774 , June 1995

Pathogenesis and Prophylaxis of Postoperative Thromboembolic Disease in Urological Pelvic Surgery

REFERENCES 

  1. Mayo ME , Halil T , Browse NL . The incidence of deep vein thrombosis after prostatectomy . Brit. J. Urol. . 1971;43:738
  2. Nicolaides AN , Field ES , Kakkar VV , Yates-Bell AJ , Taylor S , Clarke MB . Prostatectomy and deep-vein thrombosis . Brit. J. Surg. . 1972;59:487
  3. Allgood RJ , Cook JH , Weedn RJ , Speed HK , Whitcomb WH , Greenfield LJ . Prospective analysis of pulmonary embolism in the postoperative patient . Surgery . 1970;68:116
  4. Colby FH . The prevention of fatal pulmonary emboli after prostatectomy . J. Urol. . 1948;59:920
  5. Dalen JE , Alpert JS . Natural history of pulmonary embolism . Prog. Cardiovasc. Dis. . 1975;17:259
  6. Moser KM . Venous thromboembolism . Amer. Rev. Respir. Dis. . 1990;141:235
  7. Kakkar VV , Flanc C , Howe CT , Clarke MB . Natural history of postoperative deep-vein thrombosis . Lancet . 1969;2:230
  8. Morrell MT , Dunnill MS . The post-mortem incidence of pulmonary embolism in a hospital population . Brit. J. Surg. . 1968;55:347
  9. Lindblad B , Eriksson A , Bergqvist D . Autopsy-verified pulmonary embolism at a surgical department: an analysis of the period 1951 to 1988 . Brit. J. Surg. . 1991;78:849
  10. Sandler DA , Martin JF . Autopsy proven pulmonary embolism in hospital patients: are we detecting enough deep vein thrombosis? . J. Roy. Soc. Med. . 1989;82:203
  11. Clagett GP , Salzman EW . Prevention of venous thromboembolism in surgical patients . New Engl. J. Med. . 1974;290:93
  12. Moser KM . Thromboembolic disease in the patient undergoing urologic surgery . Urol. Clin. N. Amer. . 1983;10:101
  13. Hull RD , Raskob GE , Hirsh J . Prophylaxis of venous thromboembolism. An overview . Chest . 1986;89(suppl. 5):374S
  14. Prevention of venous thrombosis and pulmonary embolism . J.A.M.A. . 1986;256:744
  15. Brenner DW , Fogle MA , Schellhammer PF . Venous thromboembolism . J. Urol. . 1989;142:1403
  16. Wilner ML , Rosove MH . Hematologic considerations in urologic surgery . In:  Smith RB ,  Ehrlich RM editor. Complications in Urologic Surgery: Prevention and Management . 2nd ed.. Philadelphia: W. B. Saunders Co.; 1990;p. 41–52 chapt. 4
  17. Salzman EW , Hirsh J . The epidemiology, pathogenesis, and natural history of venous thrombosis . In:  Colman RW ,  Hirsh J ,  Marder VJ ,  Salzman EW editor. Hemostasis and Thrombosis: Basic Principles and Clinical Practice . 3rd ed.. Philadelphia: J. B. Lippincott Co.; 1994;p. 1275–1296 chapt. 65
  18. Wheeler HB . Diagnosis of deep vein thrombosis. Review of clinical evaluation and impedance plethysmography . Amer. J. Surg. . 1985;150:7
  19. Walsh PC . Radical retropubic prostatectomy . In: 6th ed..  Walsh PC ,  Retik AB ,  Stamey TA ,  Vaughan ED editor. Campbell's Urology . vol. 3: Philadelphia: W. B. Saunders Co.; 1992;p. 2865–2886 chapt. 78
  20. Igel TC , Barrett DM , Segura JW , Benson RC , Rife CC . Perioperative and postoperative complications from bilateral pelvic lymphadenectomy and radical retropubic prostatectomy . J. Urol. . 1987;137:1189
  21. Leandri P , Rossignol G , Gautier J-R , Ramon J . Radical retropubic prostatectomy: morbidity and quality of life. Experience with 620 consecutive cases . J. Urol. . 1992;147:883
  22. Pedersen KV , Herder A . Radical retropubic prostatectomy for localized prostatic carcinoma: a clinical and pathological study of 201 cases . Scand. J. Urol. Nephrol. . 1993;27:219
  23. Hautman RE , Sauter TW , Wenderoth UK . Radical retropubic prostatectomy: morbidity and urinary continence in 418 consecutive cases . Urology . 1994;43(suppl.):47
  24. Thomas PJ , Nurse DE , Deliveliotis C , Mundy AR . Cystoprostatectomy and substitution cystoplasty for locally invasive bladder cancer . Brit. J. Urol. . 1992;70:40
  25. Jahnson S , Pedersen J . Cystectomy and urinary diversion during twenty years--complications and metabolic implications . Eur. Urol. . 1993;24:343
  26. Amling CL , Thrasher JB , Frazier HA , Dodge RK , Robertson JE , Paulson DF . Radical cystectomy for stages Ta, Tis and T1 transitional cell carcinoma of the bladder . J. Urol. . 1994;151:31
  27. Becker J , Borgstrom S , Salzman GF . Occurrence and course of thrombosis following prostatectomy. A phlebographic investigation . Acta Rad. Diagn. . 1970;10:513
  28. Gordon-Smith IC , Hickman JA , El-Masri SH . The effect of the fibrinolytic inhibitor epsilon-aminocaproic acid on the incidence of deep-vein thrombosis after prostatectomy . Brit. J. Surg. . 1972;59:522
  29. Kutnowski M , Vandendris M , Steinberger R , Kraytman M . Prevention of postoperative deep-vein thrombosis by low-dose heparin in urological surgery. A double-blind, randomised study . Urol. Res. . 1977;5:123
  30. Bigg SW , Catalona WJ . Prophylactic mini-dose heparin in patients undergoing radical retropubic prostatectomy. A prospective trial . Urology . 1992;34:309
  31. Moser KM , LeMoine JR . Is embolic risk conditioned by location of deep venous thrombosis? Ann . Intern. Med. . 1981;94:439
  32. O'Donnell TF , Abbott WM , Athanasoulis CA , Millan VG , Callow AD . Diagnosis of deep venous thrombosis in the outpatient by venography . Surg., Gynec. & Obst. . 1980;150:69
  33. Doouss TW . The clinical significance of venous thrombosis of the calf . Brit. J. Surg. . 1976;63:377
  34. Philbrick JT , Becker DM . Calf deep venous thrombosis. A wolf in sheep's clothing? . Arch. Intern. Med. . 1988;148:2131
  35. Hull RD, Hirsh J, Carter CJ, Jay RM, Ockelford PA, Buller HR, et al. Diagnosis efficacy of impedance plethysmography for clinically suspected deep-vein thrombosis. A randomized trial . Ann. Intern. Med. . 1985;102:21
  36. Huisman MV , Buller HR , ten Cate JW , Vreeken J . Serial impedance plethysmography for suspected deep venous thrombosis in outpatients. The Amsterdam General Practitioner Study . New Engl. J. Med. . 1986;314:823
  37. Lensing AW, Prandoni P, Brandjes D, Huisman PM, Vigo M, Tomasella G, et al. Detection of deep-vein thrombosis by real-time B-mode ultrasonography . New Engl. J. Med. . 1989;320:342
  38. Kumar R , McKinney WP , Raj G . Perioperative prophylaxis of venous thromboembolism . Amer. J. Med. Sci. . 1993;306:336
  39. Flanc C , Kakkar VV , Clarke MB . The detection of venous thrombosis of the legs using 125-I-labelled fibrinogen . Brit. J. Surg. . 1968;55:742
  40. Wheeler HB , Anderson FA . Prophylaxis against venous thromboembolism in surgical patients . Amer. J. Surg. . 1991;161:507
  41. Pangrazzi J, Donati MB, Romero M, Scroccaro G, Colombo F, Terzian E, et al. Is there still an avoidable fraction of post-operative thromboembolic complications with heparin prophylaxis? The results of a case-control surveillance. Collaborative Group on Heparin Prophylaxis in Surgery (S.E.P.E.C) . J. Clin. Epidemiol. . 1993;46:371
  42. Virchow R . Never fall von todlicher emboli der lungeraterie . Arch. Path. Anat. . 1856;10:225
  43. Calnan JS , Allenby F . The prevention of deep vein thrombosis after surgery . Brit. J. Anaesth. . 1975;47:151
  44. Gibbs NM . Venous thrombosis of the lower limbs with particular reference to bed-rest . Brit. J. Surg. . 1957;45:15
  45. Sevitt S , Gallagher N . Venous thrombis and pulmonary embolism. A clinico-pathological study in injured and burned patients . Brit. J. Surg. . 1961;48:475
  46. Warlow C , Ogston D , Douglas AS . Deep venous thrombosis of the legs after strokes. Part I--incidence and predisposing factors . Brit. Med. J. . 1976;1:1178
  47. Wessler S , Yin ET . On the mechanism of thrombosis . Prog. Hematol. . 1969;6:201
  48. Clark C , Cotton LT . Blood-flow in deep veins of leg. Recording technique and evaluation of methods to increase flow during operation . Brit. J. Surg. . 1968;55:211
  49. Makin GS . The effect of surgical operation on the velocity of venous return from the legs . J. Surg. Res. . 1970;10:513
  50. Tripolitis AJ, Bodily KC, Blackshear WM, Cairols M, Milligan EB, Thiele BL, et al. Venous capacitance and outflow in the postoperative patient . Ann. Surg. . 1979;190:634
  51. Almen T , Nylander G . Serial phlebography of the normal lower leg during muscular contraction and relaxation . Acta Rad. . 1962;57:264
  52. Kakkar VV , Renney JT , Nicolaides AN . A modified radioactive fibrinogen test for diagnosing deep-vein thrombosis of the legs . Brit. J. Surg. . 1970;57:382
  53. Nicolaides AN , Kakkar VV , Renney JT . Soleal sinuses and stasis . Brit. J. Surg. . 1971;58:307
  54. Rosenberg RD , Rosenberg JS . Natural anticoagulant mechanisms . J. Clin. Invest. . 1984;74:1
  55. Busch C , Owen WG . Identification in vitro of an endothelial cell surface cofactor for antithrombin III. Parallel studies with isolated perfused rat hearts and microcarrier cultures of bovine endothelium . J. Clin. Invest. . 1982;69:726
  56. Esmon NL , Owen WG , Esmon CT . Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C . J. Biol. Chem. . 1982;257:859
  57. Erickson LA , Schleef RR , Ny T , Loskutoff DJ . The fibrinolytic system of the vascular wall . Clin. Haematol. . 1985;14:513
  58. Wilner GD , Nossel HL , LeRoy EC . Activation of Hageman factor by collagen . J. Clin. Invest. . 1968;47:2608
  59. Walsh PN , Griffin JH . Contributions of human platelets to the proteolytic activation of blood coagulation factors XII and XI . Blood . 1981;57:106
  60. Coleridge-Smith PD , Hasty JH , Scurr JH . Venous stasis and vein lumen changes during surgery . Brit. J. Surg. . 1990;77:1055
  61. Comerota AJ , Stewart GJ , Alburger PD , Smalley K , White JV . Operative venodilation: a previously unsuspected factor in the cause of postoperative deep vein thrombosis . Surgery . 1989;106:301
  62. Bauer KA , Kass BL , ten Cate H , Hawiger JJ , Rosenberg RD . Factor IX is activated in vivo by the tissue factor mechanism . Blood . 1990;76:731
  63. Bauer KA , Weiss LM , Sparrow D , Vokonas PS , Rosenberg RD . Aging-associated changes in the indices of thrombin generation and protein C activation in humans. Normative Aging Study . J. Clin. Invest. . 1987;80:1527
  64. Gordon SG , Franks JJ , Lewis B . Cancer procoagulant A: a factor × activating procoagulant from malignant tissue . Thromb. Res. . 1975;6:127
  65. Esparaz B , Green D . A study of proteins C and S in patients with prostatic disease. Letter to the Editor . Thromb. Haemost. . 1988;60:122
  66. Al-Mondhiry H , Manni A , Owen J , Gordon R . Hemostatic effects of hormonal stimulation in patients with metastatic prostate cancer . Amer. J. Hematol. . 1988;28:141
  67. Dobbs RM , Barber JA , Weigel JW , Bergin JE . Clotting predisposition in carcinoma of the prostate . J. Urol. . 1980;123:706
  68. Ham JM , Jones M , Kemp D . Platelet adhesiveness and lipoprotein lipase activity in patients with benign and malignant disease of the prostate . Brit. J. Surg. . 1972;59:60
  69. Pineo GF , Regoeczi E , Hatton MW , Brain ML . The activation of coagulation by extracts of mucus: a possible pathway of intravascular coagulation accompanying adenocarcinomas . J. Lab. Clin. Med. . 1973;82:255
  70. Wojtukiewicz MZ, Zacharski LR, Memoli VA, Kisiel W, Kudryk BJ, Moritz TE, et al. Fibrin formation on vessel walls in hyperplastic and malignant prostate tissue . Cancer . 1991;67:1377
  71. Moore KL , Andreoli SP , Esmon NL , Esmon CT , Bang NU . Endotoxin enhances tissue factor and suppresses thrombomodulin expression of human vascular endothelium in vitro . J. Clin. Invest. . 1987;79:124
  72. Conway EM , Rosenberg RD . Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells . Mol. Cell Biol. . 1988;8:5588
  73. Medina R , Socher SH , Han JH , Friedman PA . Interleukin-1, endotoxin, or tumor necrosis factor/cachectin enhance the level of plasminogen activator inhibitor messenger RNA in bovine aortic endothelial cells . Thromb. Res. . 1989;54:41
  74. Dittman WA , Majerus PW . Structure and function of thrombomodulin: a natural anticoagulant . Blood . 1990;75:329
  75. Stewart GJ . Neutrophils and deep venous thrombosis . Haemostasis . 1993;23(suppl.):127
  76. Hirsh J , Salzman EW , Marder VJ , Colman RW . Overview of the thrombotic process and its therapy . In: Hemostasis and Thrombosis: Basic Principles and Clinical Practice . 3rd ed.. Philadelphia: J. B. Lippincott Co.; 1994;p. 1151–1163 chapt. 57
  77. Ygge J . Changes in blood coagulation and fibrinolysis during the postoperative period . Amer. J. Surg. . 1970;119:225
  78. Mansfield AO . Alteration in fibrinolysis associated with surgery and venous thrombosis . Brit. J. Surg. . 1972;59:754
  79. Gallus AS , Hirsh J , Gent M . Relevance of preoperative and postoperative blood tests to postoperative leg-vein thrombosis . Lancet . 1973;2:805
  80. Leibovitch I , Ben Chaim J , Raviv G , Mor Y , Avigad I , Goldwasser B . Quantitative changes in platelet counts following major urological pelvic surgery . Eur. Urol. . 1993;24:350
  81. Collins R , Scrimgeour A , Yusuf S , Peto R . Reduction in fatal pulmonary embolism and venous thrombosis by perioperative administration of subcutaneous heparin. Overview of results of randomized trials in general, orthopedic, and urologic surgery . New Engl. J. Med. . 1988;318:1162
  82. Williams HT . Prevention of postoperative deep-vein thrombosis with perioperative subcutaneous heparin . Lancet . 1971;2:950
  83. Kakkar VV, Corrigan T, Spindler J, Fossard DP, Flute PT, Crellin RO, et al. Efficacy of low doses of heparin in the prevention of deep-vein thrombosis after major surgery. A double-blind, randomised trial . Lancet . 1972;2:101
  84. Prevention of fatal postoperative pulmonary embolism by low doses of heparin. An international multicentre trial . Lancet . 1975;2:45
  85. Colditz GA , Tuden RL , Oster G . Rates of venous thrombosis after general surgery: combined results of randomised clinical trials . Lancet . 1986;2:143
  86. Clagett GP , Reisch JS . Prevention of venous thromboembolism in general surgical patients. Results of meta-analysis . Ann. Surg. . 1988;208:227
  87. Sebeseri O , Kummer H , Zingg E . Controlled prevention of post-operative thrombosis in urological diseases with depot heparin . Eur. Urol. . 1975;1:229
  88. Vandendris M , Kutnowski M , Futeral B , Gianakopoulos X , Kraytman M , Gregoir W . Prevention of postoperative deep-vein thrombosis by low-dose heparin in open prostatectomy . Urol. Res. . 1980;8:219
  89. Pachter HL , Riles TS . Low dose heparin: bleeding and wound complications in the surgical patient. A prospective randomized study . Ann. Surg. . 1977;186:669
  90. van Ooijen B . Subcutaneous heparin and postoperative wound hematomas. A prospective, double-blind, randomized study . Arch. Surg. . 1986;121:937
  91. Levine MN , Hirsh J , Landefeld S , Raskob G . Hemorrhagic complications of anticoagulant treatment . Chest . 1992;102(suppl.):352S
  92. Halverstadt DB , Albers DD , Kroovand RL , Rich R . Anticoagulation in urologic surgery . Urology . 1977;9:617
  93. Jasper WS . Anticoagulants in open prostatectomies . J. Urol. . 1977;117:72
  94. Catalona WJ , Kadmon D , Crane DB . Effect of mini-dose heparin on lymphocele formation following extraperitoneal pelvic lymphadenectomy . J. Urol. . 1980;123:890
  95. Koonce J , Selikowitz S , McDougal WS . Complications of low-dose heparin prophylaxis following pelvic lymphadenectomy . Urology . 1986;28:21
  96. Boshkov LK , Warkentin TE , Hayward CP , Andrew M , Kelton JG . Heparin-induced thrombocytopenia and thrombosis: clinical and laboratory studies . Brit. J. Haematol. . 1993;84:322
  97. Kelton JG . Heparin-induced thrombocytopenia . Haemostasis . 1986;16:173
  98. Silver D , Kapsch DN , Tsoi EK . Heparin-induced thrombocytopenia, thrombosis, and hemorrhage . Ann, Surg. . 1983;198:301
  99. Hirsh J , Dalen JE , Deykin D , Poller L . Heparin: mechanism of action, pharmacokinetics, dosing considerations, monitoring, efficacy, and safety . Chest . 1992;102(suppl.):337S
  100. Yun SK , Zimmern PE , Lad P . Glycosaminoglycans in urology . AUA Update Series . 1994;13:190
  101. Caprini JA , Arcelus JI , Traverso CI , Hasty JH . Low molecular weight heparins and external pneumatic compression as options for venous thromboembolism prophylaxis: a surgeon's perspective . Sem. Thromb. Hemost. . 1991;17:356
  102. Gallus AS , Saltzman EW , Hirsh J . Prevention of venous thromboembolism . In:  Colman RW ,  Hirsh J ,  Marder VJ ,  Salzman EW editor. Hemostasis and Thrombosis: Basic Principles and Clinical Practice . 3rd ed.. Philadelphia: J. B. Lippincott Co.; 1994;p. 1331–1345 chapt. 68
  103. Nurmohamed MT, Rosendaal FR, Buller HR, Dekker E, Hommes DW, Vandenbroucke JP, et al. Low-molecular-weight heparin versus standard heparin in general and orthopaedic surgery: a meta-analysis . Lancet . 1992;340:152
  104. Gallus A, Cade J, Ockelford P, Hepburn S, Maas M, Magnani H, et al. Orgaran (Org 10172) or heparin for preventing venous thrombosis after elective surgery for malignant disease? A double-blind, randomised, multicentre comparison. ANZ-Organon Investigators' Group . Thromb. Haemost. . 1993;70:562
  105. Kakkar VV, Cohen AT, Edmonson RA, Phillips MJ, Cooper DJ, Das SK, et al. Low molecular weight versus standard heparin for prevention of venous thromboembolism after major abdominal surgery. The Thromboprophylaxis Collaborative Group . Lancet . 1993;341:259
  106. Jorgensen LN , Wille-Jorgensen P , Hauch O . Prophylaxis of postoperative thromboembolism with low molecular weight heparins . Brit. J. Surg. . 1993;80:689
  107. Prandoni P, Meduri F, Cuppini S, Toniato A, Zangrandi F, Polistena P, et al. Dermatan sulphate: a safe approach to prevention of postoperative deep vein thrombosis . Brit. J. Surg. . 1992;79:505
  108. The Multicenter Trial Committee: Dihydroergotamine-heparin prophylaxis of postoperative deep vein thrombosis: a multicenter trial . J.A.M.A. . 1984;251:2960
  109. Hansberry KL , Thompson IM , Bauman J , Deppe S , Rodriguez FR . A prospective comparison of thromboembolic stockings, external sequential pneumatic compression stockings and heparin sodium/dihydroergotamine mesylate for the prevention of thromboembolic complications in urological surgery . J. Urol. . 1991;145:1205
  110. Nicolaides AN , Fernandes J , Pollock AV . Intermittent sequential pneumatic compression of the legs in the prevention of venous stasis and postoperative deep venous thrombosis . Surgery . 1980;87:69
  111. Knight MT , Dawson R . Effect of intermittent compression of the arms on deep venous thrombosis in the legs . Lancet . 1976;2:1265
  112. Tarnay TJ , Rohr PR , Davidson AG , Stevenson MM , Byars EF , Hopkins GR . Pneumatic calf compression, fibrinolysis, and the prevention of deep venous thrombosis . Surgery . 1980;88:489
  113. Caprini JA , Chucker JL , Zuckerman L , Vagher JP , Franck CA , Cullen JE . Thrombosis prophylaxis using external compression . Surg., Gynec. & Obst. . 1983;156:599
  114. Guyton DP , Khayat A , Schreiber H . Pneumatic compression stockings and prostaglandin synthesis--a pathway of fibrinolysis? Crit . Care Med. . 1985;13:266
  115. Nicolaides AN , Miles C , Hoare M , Jury P , Helmis E , Venniker R . Intermittent sequential pneumatic compression of the legs and thromboembolism-deterrent stockings in the prevention of postoperative deep venous thrombosis . Surgery . 1983;94:21
  116. Baker WH, Mahler DK, Foldes MS, Michelini MA, Hayes AC, Littooy FN, et al. Pneumatic compression devices for prophylaxis of deep venous thrombosis (DVT) . Amer. Surg. . 1986;52:371
  117. Scurr JH , Coleridge-Smith PD , Hasty JH . Regimen for improved effectiveness of intermittent pneumatic compression in deep venous thrombosis prophylaxis . Surgery . 1987;102:816
  118. Hull RD, Raskob GE, Gent M, McLoughlin D, Julian D, Smith FC, et al. Effectiveness of intermittent pneumatic compression for preventing deep vein thrombosis after total hip replacement . J.A.M.A. . 1990;263:2313
  119. Salzman EW, McManama GP, Shapiro AH, Robertson LK, Donovan AS, Blume HW, et al. Effect of optimization of hemodynamics on fibrinolytic activity and antithrombotic efficacy of external pneumatic calf compression . Ann. Surg. . 1987;206:636
  120. Coe NP, Collins REC, Klein LA, Bettmann MA, Skillman JJ, Shapiro RM, et al. Prevention of deep vein thrombosis in urological patients: a controlled, randomized trial of low-dose heparin and external pneumatic compression boots . Surgery . 1978;83:230
  121. Salzman EW , Ploetz J , Bettmann M , Skillman J , Klein L . Intraoperative external pneumatic calf compression to afford long-term prophylaxis against deep vein thrombosis in urological patients . Surgery . 1980;87:239
  122. Van Arsdalen KN , Smith MJV , Barnes RW , Koontz WW , Clarke G . Deep vein thrombosis and prostatectomy . Urology . 1983;21:461
  123. Cisek LJ , Walsh PC . Thromboembolic complications following radical retropubic prostatectomy: influence of external sequential pneumatic compression devices . Urology . 1993;42:406
  124. Strup SE , Gudziak M , Mulholland SG , Gomella LG . The effect of intermittent pneumatic compression devices on intraoperative blood loss during radical prostatectomy and radical cystectomy . J. Urol. . 1993;150:1176
  125. Sigel B , Edelstein AL , Felix WR , Memhardt CR . Compression of the deep venous system of the lower leg during inactive recumbency . Arch. Surg. . 1973;106:38
  126. Wells PS , Lensing AW , Hirsh J . Graduated compression stockings in the prevention of postoperative venous thromboembolism. A meta-analysis . Arch. Intern. Med. . 1994;154:67
  127. Imperiale TF , Speroff T . A meta-analysis of methods to prevent venous thromboembolism following total hip replacement . J.A.M.A. . 1994;271:1780
  128. Lassen HK . Preoperative and postoperative anticoagulant prophylaxis to reduce fatal pulmonary embolism at a mixed surgical department . Acta Chir. Scand. . 1968;134:525
  129. Kakkar VV . Prevention of fatal pulmonary embolism . Haemostasis . 1993;23(suppl.):42
  130. O'Reilly RA . Anticoagulant, antithrombotic, and thrombolytic drugs . In:  Gilman AG ,  Goodman LS ,  Rall TW ,  Murad F editor. The Pharmacologic Basis of Therapeutics . New York: MacMillan Publishing Co.; 1985;p. 1338–1359 chapt. 58
  131. Hirsh J , Dalen JE , Deykin D , Poller L . Oral anticoagulants. Mechanism of action, clinical effectiveness, and optimal therapeutic range . Chest . 1992;102(suppl.):312S
  132. Andersen R , Jensen PB . Prophylactic anticoagulant therapy in prostate surgery . Acta Chir. Scand. . 1966;132:444
  133. Holbraad L , Thybo E , Vennitis H . A controlled investigation of the value of anticoagulation therapy in cases of prostatectomy . Scand. J. Urol. Nephrol. . 1976;10:39
  134. Chandhoke PS , Gooding GAW , Narayan P . Prospective randomized trial of warfarin and intermittent pneumatic leg compression as prophylaxis for postoperative deep venous thrombosis in major urologic surgery . J. Urol. . 1992;147:1056
  135. Salzman EW , Davies GC . Prophylaxis of venous thromboembolism: analysis of cost effectiveness . Ann. Surg. . 1980;191:207
  136. Dale J , Myhre E , Loew D . Bleeding during acetylsalicylic acid and anticoagulant therapy in patients with reduced platelet reactivity after aortic valve replacement . Amer. Heart J. . 1980;99:746
  137. Chesebro JH, Fuster V, Elveback LR, McGoon DC, Pluth JR, Puga FJ, et al. Trial of combined warfarin plus dipyridamole or aspirin therapy in prosthetic heart valve replacement: danger of aspirin compared with dipyridamole . Amer. J. Cardiol. . 1983;51:1537
  138. Landefeld CS , Goldman L . Major bleeding in outpatients treated with warfarin: incidence and prediction by factors known at the start of outpatient therapy . Amer. J. Med. . 1989;87:144
  139. Francis CW , Marder VJ , Evarts CM , Yaukoolbodi S . Two-step warfarin therapy. Prevention of postoperative venous thrombosis without excessive bleeding . J.A.M.A. . 1983;249:374
  140. Poller L , McKernan A , Thomson JM , Elstein M , Hirsch PJ , Jones JB . Fixed minidose warfarin: a new approach to prophylaxis against venous thrombosis after major surgery . Brit. Med. J. . 1987;295:1309
  141. MacCallum PK , Thomson JM , Poller L . Effects of fixed minidose warfarin on coagulation and fibrinolysis following major gynaecological surgery . Thromb. Haemost. . 1990;64:511
  142. Coventry MB , Nolan DR , Beckenbaugh RD . “Delayed” prophylactic anticoagulation: a study of results and complications in 2,012 total hip arthroplasties . J. Bone Joint Surg. . 1973;55:1487
  143. Powers PJ, Gent M, Jay RM, Julian DH, Turpie AGG, Levine M, et al. A randomized trial of less intense postoperative warfarin or aspirin therapy in the prevention of venous thromboembolism after surgery for fractured hip . Arch. Intern. Med. . 1989;149:771
  144. Broekmans AW , Bertina RM , Loeliger EA , Hofmann V , Klingemann HG . Protein C and the development of skin necrosis during anticoagulant therapy . Thromb. Haemost. . 1983;49:251
  145. Grimaudo V , Gueissaz F , Hauert J , Sarraj A , Kruithof EK , Bachmann F . Necrosis of skin induced by coumadin in a patient deficient in protein S . Brit. Med. J. . 1989;298:233
  146. Buckley NA , Dawson AH . Drug interactions with warfarin . Med. J. Aust. . 1992;157:479
  147. Gruber UF, Saldeen T, Brokop T, Eklof B, Eriksson I, Goldie I, et al. Incidences of fatal postoperative pulmonary embolism after prophylaxis with dextran 70 and low-dose heparin: an international multicentre study . Brit. Med. J. . 1980;280:69
  148. Bonnar J , Walsh J . Prevention of thrombosis after pelvic surgery by British dextran 70 . Lancet . 1972;1:614
  149. Ljungstrom KG , Renck H , Strandberg K , Hedim H , Richter W , Widerlov E . Adverse reactions to dextran in Sweden 1970-79 . Acta Chir. Scand. . 1983;149:253
  150. Clagett GP , Schneider P , Rosoff CB , Saltzman EW . The influence of aspirin on postoperative platelet kinetics and venous thrombosis . Surgery . 1975;77:61
  151. Renney JT , O'Sullivan EF , Burke PF . Prevention of postoperative deep vein thrombosis with dipyridamole and aspirin . Brit. Med. J. . 1976;1:992
  152. Hirsh J , Dalen JE , Fuster V , Harker LB , Salzman EW . Aspirin and other platelet-active drugs. The relationship between dose, effectiveness, and side effects . Chest . 1992;102(suppl.):327S
  153. Flower RJ , Moncada S , Van JR . Analgesic-antipyretics and anti-inflammatory agents; drugs employed in the treatment of gout . In:  Gilman AG ,  Goodman LS ,  Rall TW ,  Murad F editor. The Pharmacological Basis of Therapeutics . 7th ed.. New York: Macmillan Publishing Co.; 1985;p. 674–715 chapt. 29
  154. Harris WH , Athanasoulis CA , Waltman AC , Salzman EW . Prophylaxis of deep-vein thrombosis after total hip replacement. Dextran and external pneumatic compression compared with 1.2 or 0.3 gram of aspirin daily . J. Bone Joint Surg. . 1985;67:57
  155. Cotton TL . The prevention of deep vein thrombosis, with particular reference to mechanical methods of prevention . Surgery . 1977;81:228
  156. Scurr JH , Coleride-Smith PD , Hasty JH . Deep venous thrombosis: a continuing problem . Brit. Med. J. . 1988;297:28
  157. Sorensen C , Andersen M , Kristiansen VB , Jensen R , Wille-Jorgensen P . The occurrence of late thromboembolic complications after elective abdominal surgery . Useskr Laeger . 1990;152:1586
  158. Huber O , Bounameaux H , Borst F , Rohner A . Postoperative pulmonary embolism after hospital discharge: an underestimated risk . Arch. Surg. . 1992;127:310
  159. Wille-Jorgensen P , Lausen I , Nannestad Jorgensen L . Is there a need for long-term thromboprophylaxis following general surgery? . Haemostasis . 1993;23(suppl.):10
  160. Hedlund PO , Blomback M . The effects of low-dose heparin treatment on patients undergoing transvesical prostatectomy . Urol. Res. . 1981;9:147
  161. Koch MO , Smith JA , Hodge EM , Brandell RA . Prospective development of a cost-efficient program for radical retropubic prostatectomy . Urology . 1994;44:311
  162. Prostate surgery expenses, 1991 . Statistical Bull. . 1993;74:18
  163. Arcelus JI , Caprini JA , Traverso CI . Venous thromboembolism after hospital discharge . Semin. Thromb. Hemost. . 1993;19(suppl.):142
  164. Bergqvist D . Long-term prophylaxis following orthopedic surgery . Haemostasis . 1993;23(suppl.):27

PII: S0022-5347(01)67302-6

The Journal of Urology
Volume 153, Issue 6 , Pages 1763-1774 , June 1995