Papaverine-Phentolamine and Prostaglandin E1 Versus Papaverine-Phentolamine Alone For Intracorporeal Injection Therapy: A Clinical Double-Blind Study

Abstract 

Purpose

A study was designed to compare intracorporeal injections of papaverine plus phentolamine (2-drug solution) and papaverine plus phentolamine and prostaglandin E1 (3-drug solution) for the treatment for impotence.

Materials and Methods

A total of 20 impotent patients received intracorporeal injections of the 2-drug or 3-drug solution alternately during 2 sessions, and the quality and duration of erections were assessed.

Results

Of the patients 73 percent achieved a full erection with the 3-drug solution compared to 28 percent with the 2-drug solution. The average duration of erections was 57 minutes and 33.6 minutes, respectively. The complication rate was similar for the 2 treatments.

Conclusions

Papaverine plus phentolamine and prostaglandin E1 is superior to papaverine plus phentolamine alone for the treatment of impotence.