The Journal of Urology
Volume 155, Issue 4 , Pages 1436-1438 , April 1996

High Levels of Soluble p55-TNF Receptors in Seminal and Prostatic Fluids of Normal and Infertile Men

,Accepted 25 August 1995.

REFERENCES 

  1. Hales DB , Xiong Y , Tur-Kaspa I . The role of cytokines in the regulation of Leydig cell P450c17 gene expression . J. Steroid Biochem. Mol. Biol. . 1992;43:907
  2. Xiong Y , Hales DB . The role of tumor necrosis factor in the regulation of mouse Leydig cell steroidogenesis . Endocrinology . 1993;132:2438
  3. Hill JA , Haimovici F , Politch JA , Anderson DJ . Effects of soluble products of activated lymphocytes and macrophages (lymphokines and monokines) on human sperm motion parameters . Fertil. Steril. . 1987;47:460
  4. Eisermann J , Register KB , Strickler RC , Collins JL . The effect of tumor necrosis factor on human sperm motility in vitro . J. Androl. . 1989;10:270
  5. Haney AF , Hughes SF , Weinberg JB . The lack of effect of tumor necrosis factor-alpha, interleukin-1-alpha, and interferon-gamma on human sperm motility in vitro . J. Androl. . 1992;13:249
  6. Wincek TJ , Meyer MR , Kuehl TJ . Absence of a direct effect of recombinant tumor necrosis factor-alpha on human sperm function and murine preimplantation development . Fertil. Steril. . 1991;56:332
  7. Engelman H , Novick D , Wallach D . Two tumor necrosis factor-binding proteins purified from human urine . Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors. J. Biol. Chem. . 1990;265:1531
  8. Seckinger P , Isaaz S , Dayer M . Purification and biologic characterization of a specific tumor necrosis factor inhibitor . J. Biol. Chem. . 1989;264:11966
  9. Nophar Y, Kemper O, Brakebusch C, Engelmann H, Zwang R, Aderka D, et al. Soluble forms of tumor necrosis factors (TNF-Rs). The cDNA for the type I TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form of the receptor . E.M.B.O. J. . 1990;9:3269
  10. Aderka D , Engelman H , Maor Y , Brakebusch C , Wallach D . Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors . J. Exp. Med. . 1992;323:323
  11. Aderka D, Engelmann H, Hornik V, Skornick Y, Levo Y, Wallach D, et al. Increased serum levels of soluble receptors for tumor necrosis factor in cancer patients . Cancer Res. . 1991;51:5602
  12. Olsson I , Gatanaga T , Gullberg U , Lantz M , Granger GA . Tumor necrosis factor (TNF) binding proteins (soluble TNF receptor forms) with possible roles in inflammation and malignancy . Eur. Cytokine Netw. . 1993;4:169
  13. Aderka D, Engelmann H, Shemer-Avni Y, Hornick V, Galil A, Sarov B, et al. Variation in serum levels of the soluble TNF receptors among healthy individuals . Lymphokine Cytokine Res. . 1992;11:157
  14. Cope AP, Aderka D, Doherty M, Engelman H, Gibbons D, Jones AC, et al. Soluble tumor necrosis factor (TNF) receptors are upregulated in the sera and synovial fluids of patients with rheumatic disease . Arthritis Rheum. . 1992;35:1160
  15. Aderka D, Wysenbeek A, Engelmann H, Cope AP, Brennan F, Molad Y, et al. Correlation between serum levels of soluble tumor necrosis factor receptors and disease activity in systemic lupus erythematosus . Arthrit. Rheum. . 1993;36:1111
  16. Waage A , Liabakk N , Lien E , Lamvik J , Espevik T . p55 and p75 tumor necrosis factor receptors in patients with chronic lymphocytic leukemia . Blood . 1992;80:2577
  17. Liabakk NB , Lien E , Sundan A , Sunde A , Austgulen R , Espevik T . High concentration of the soluble p55 tumor necrosis factor receptor in human seminal plasma . Hum. Reprod. . 1993;8:1837
  18. Liu S, Ewing MW, Anglard P, Trahan E, LaRocca RV, Meyers CE, et al. The effect of suramin, tumor necrosis factor and interferon gamma on human prostate carcinoma . J. Urol. . 1991;145:389
  19. Sherwood ER , Ford TR , Lee C , Kozlowski JM . Therapeutic efficacy of recombinant tumor necrosis factor alpha in an experimental model of human prostatic carcinoma . J. Biol. Response Mod. . 1990;9:44
  20. Iizumi T , Yazaki T , Umeda T , Soma GI . Promotion of metastases by tumor necrosis factor in rats bearing Dunning R3327 MAT-LyLu prostatic cancer . Urol. Int. . 1993;51:85

 This work was supported in part by grant No. 2967 from the Chief Scientist's Office of the Ministry of Health, Israel and by a grant from Inter-Lab., Ness-Ziona, Israel and by the Ministry of Health.

PII: S0022-5347(01)66302-X

The Journal of Urology
Volume 155, Issue 4 , Pages 1436-1438 , April 1996