The Association of Increasing Body Mass Index and Kidney Stone Disease
Received 29 May 2009 published online 16 December 2009.
Refers to article:
Body Mass Index as a Predictor of Urological Disease and Outcomes—Overly Simplistic?
, 14 December 2009
Viraj A. Master
The Journal of Urology
February 2010 (Vol. 183, Issue 2, Pages 427-429) Full Text |
Full-Text PDF (113 KB)
Ethylene Glycol Induced Hyperoxaluria Increases Plasma and Renal Tissue Asymmetrical Dimethylarginine in Rats: A New Pathogenetic Link in Hyperoxaluria Induced Disorders
, 17 December 2009
Hasan Aydın, Faruk Yencilek, Nilgün Mutlu, Nil Çomunoğlu, Hasbey Hakan Koyuncu, Kemal Sarıca
The Journal of Urology
February 2010 (Vol. 183, Issue 2, Pages 759-764) Abstract |
Full Text |
Full-Text PDF (1219 KB)
Purpose
Previous epidemiological works have reported that obesity is a risk factor for kidney stone disease. However, the effect of increasing degrees of obesity on stone formation has yet to be defined. To address this question we examined how an increasing body mass index affects the risk of kidney stone disease.
Materials and Methods
We evaluated claims from a 5-year period (2002 to 2006) in a national private insurance database to identify subjects diagnosed with or treated for kidney stones. From a data set of 95,598 patients, subjects were identified by ICD-9 or CPT codes specific to kidney stone disease. Descriptive analyses were performed and odds ratios were calculated.
Results
Gender distribution of the 3,257 stone formers was 42.9% male and 57.1% female. Obesity (body mass index greater than 30 kg/m2) was associated with a significantly greater likelihood of being diagnosed with a kidney stone. However, when obese patients were stratified by body mass index there were no significant differences in the likelihood of a kidney stone diagnosis, suggesting a stabilization of risk once body mass index increased above 30 kg/m2. The association of body mass index and a stone removal procedure was significant only for men and women with a body mass index between 30 and 45 kg/m2 relative to a body mass index less than 25 kg/m2 (p <0.001).
Conclusions
An obese body mass index is associated with an increased risk of kidney stone disease. However, the magnitude of this risk appears to be stable in the morbidly obese population. Once body mass index is greater than 30 kg/m2, further increases do not appear to significantly increase the risk of stone disease.
Johns Hopkins University School of Medicine, Baltimore, Maryland
Correspondence: The James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, 600 North Wolfe St., Baltimore, Maryland 21287 (telephone: 410-502-7710; FAX: 410-502-7711)
Supported by The Hariri Family Foundation, and Mr. and Mrs. Chad and Nissa Richison.
Supported by Grant T32DK07552 from the National Institutes of Health-National Institute of Diabetes and Digestive and Kidney Diseases. The contents are solely the responsibility of the author, and do not necessarily represent the official views of the National Institutes of Health-National Institute of Diabetes and Digestive and Kidney Diseases.
The data set used in this study was originally created for a different research project on patterns of obesity care within selected BCBS plans. The previous research project (but not the current study) was funded by unrestricted research grants from Ethicon Endo-Surgery, Inc. (a Johnson & Johnson company); Pfizer, Inc and GlaxoSmithKline.
See Editorial on page 427.
For another article on a related topic see page 759.
ABSTRACT